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Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) ELISA Kits

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SNCA SNCA 20617 O55042
Anti-Human SNCA SNCA 6622 P37840
Anti-Rat SNCA SNCA 29219 P37377
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More ELISA Kits for Synuclein, alpha (Non A4 Component of Amyloid Precursor) Interaction Partners

Rhesus Monkey Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.

Mouse (Murine) Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

  2. alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.

  3. In the olfactory bulb, globus pallidus and substantia nigra pars (show EPRS ELISA Kits) compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.

  4. identified alpha-synuclein as a new transcriptional target of p53 (show TP53 ELISA Kits)

  5. High SNCA expression is associated with epilepsy.

  6. Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.

  7. that loss of glucocerebrosidase (show GBA ELISA Kits) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation

  8. provides evidence for a novel interaction of alpha-synuclein and SOD1 (show SOD1 ELISA Kits) that might be relevant for neurodegenerative diseases

  9. It found that chromosome 1 harbors an expression quantitative trait locus that modulates Sncg (show SNCG ELISA Kits) expression in the mouse retina, and identified the prefoldin-2 (PFDN2 (show PFDN2 ELISA Kits)) gene as the candidate upstream modulator of Sncg (show SNCG ELISA Kits) expression.

  10. The response of CPLX1 (show CPLX1 ELISA Kits) and Foxp1 (show FOXP1 ELISA Kits) levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.

Human Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. Using deletion mutants, the acidic C-terminal region of alpha-synuclein and the basic central region of Tau were identified as binding regions. Introduction of alpha-synuclein fibrils into cells overexpressing Tau induced Tau aggregation, raising the possibility that alpha-synuclein fibrils interact with Tau, inhibit its function to stabilize microtubules, and also promote Tau aggregation, leading to dysfunction of neu...

  2. alpha-Synuclein, a presynaptic neuronal protein (show LRCH1 ELISA Kits), is not only a marker but also plays a role in the spread of Parkinson disease. Review.

  3. The present study demonstrates that the Syn (show FYN ELISA Kits) pathology may be linked to colic neuronal degeneration during normal aging, and this link may cause functional deficits.

  4. SNCA gene polymorphism may be associated with an increased risk of AD and GG genotype of rs10516846 and elevated SNCA level in CSF (show CSF2 ELISA Kits) may increase the risk of early-onset Alzheimer's Disease.

  5. The results of this study suggested SNCA mutations to be screened in familial and early onset Chinese Parkinson disease patients.

  6. LAG3 (show LAG3 ELISA Kits) binds alpha-synuclein preformed fibrils (PFF) with high affinity (dissociation constant = 77 nanomolar), whereas the alpha-syn monomer exhibited minimal binding. alpha-Syn-biotin PFF binding to LAG3 (show LAG3 ELISA Kits) initiated alpha-syn PFF endocytosis, transmission, and toxicity.

  7. An increase in striatal glial fibrillary acidic protein (show GFAP ELISA Kits) mRNA level 4 weeks after ASN injection into the ST.

  8. these findings provide an evidence that the region from 32 to 58 of N-terminal lipid binding alpha helix domain of SNCA is the most critical region, not only from the evolutionary perspective but also for the stability and the proper conformation of the protein as well as crucial for the disease pathogenesis, harboring critical interaction sites.

  9. This mathematical approach confirmed the clustering of premotor markers in preclinical stage of Parkinson's disease. This is the first report showing that alpha-synuclein in the colon and other premotor markers are related to each other in neurologically normal subjects.

  10. Hypomethylation of CpG islands located in intron 1 of the SNCA in leukocytes of dementia with Lewy bodies.

Cow (Bovine) Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) Antigen Profile

Antigen Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Gene names and symbols associated with SNCA

  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA) antibody
  • alpha-synuclein (LOC100359228) antibody
  • alpha-synuclein-like (SNCA) antibody
  • synuclein, alpha (Snca) antibody
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca) antibody
  • alphaSYN antibody
  • NACP antibody
  • PARK1 antibody
  • PARK4 antibody
  • PD1 antibody

Protein level used designations for SNCA

alpha SYN , alpha-synuclein , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

GENE ID SPECIES
100053270 Equus caballus
100359228 Oryctolagus cuniculus
706985 Macaca mulatta
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
478478 Canis lupus familiaris
282857 Bos taurus
641350 Sus scrofa
395393 Gallus gallus
100725375 Cavia porcellus
100294604 Ovis aries
100190854 Pongo abelii
461375 Pan troglodytes
100984304 Pan paniscus
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