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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein.
Overexpression of mutant alpha-synuclein causes age-dependent pathological changes in brain.
C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 (show MMRN1 ELISA Kits) genes, have an altered bone phenotype.
The findings of this study indicated a functional role of alpha-synuclein in early experimental autoimmune encephalomyelitis by increasing Th1 (show HAND1 ELISA Kits) cell-mediated immune response.
These data show that neurodegenerative processes associated with lysosomal dysfunction may be presynaptically initiated by a concomitant reduction in alpha-synuclein and CSPalpha levels at nerve terminals.
Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.
LRRK2 (show LRRK2 ELISA Kits) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (show LRRK2 ELISA Kits) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.
sideroflexin 3 (SFXN3 (show SFXN3 ELISA Kits)) was found to be a mitochondrial protein (show COX6B2 ELISA Kits) localized to the inner mitochondrial membrane.
The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation
Rab7 (show RAB7A ELISA Kits) accumulated in GCase (show GBA ELISA Kits) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (show GBA ELISA Kits) can reverse ALR (show GFER ELISA Kits) impairment, we anticipate that strategies to restore GCase (show GBA ELISA Kits) activity in the brains of both sporadic patients with PD and those with GBA1 (show GBA ELISA Kits) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 can protect the immature brain against cell apoptosis induced by LPS-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS-sensitized HI brain damage in PINK1-knockout neonatal mice
Genetic manipulation of sirtuin 2 (show SIRT2 ELISA Kits) levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.
RER1 (show RER1 ELISA Kits) is a novel and potential important mediator of elevated alphaSyn levels
Results show that both alphaS and NFL (show NEFL ELISA Kits) can be phosphorylated by CKII (show CSNK2A1 ELISA Kits), PLK2 (show PLK2 ELISA Kits) and PLK3 (show PLK3 ELISA Kits), but Ser129 in alphaS is a preferential site for PLK2 (show PLK2 ELISA Kits) and PLK3 (show PLK3 ELISA Kits), demonstrating higher phosphorylation efficiency. Comparatively, CKII (show CSNK2A1 ELISA Kits) preferentially phosphorylates Ser473 in NFL (show NEFL ELISA Kits) and this site can be phosphorylated by PLK1 (show PLK1 ELISA Kits), 2 and 3, but these enzymes prefer to modify other sites within NFL (show NEFL ELISA Kits).
two morphologically different alpha-synuclein fibrils, one helical and the other ribbon-like, are shown to form together. Surprisingly, a widely used small molecule for probing aggregation reactions, thioflavin T (ThT), was found to tune the structural heterogeneity found in the fibrils.
results indicated that the dismal prognosis of patients with HBsAg+ may be related to the high rate of PD1 (show PDCD1 ELISA Kits) expression. Thus, a targeted PD1 (show PDCD1 ELISA Kits) treatment strategy may improve the prognosis of HBsAg+ DLBCL patients
PD-1 (show PDCD1 ELISA Kits) in osteosarcoma patients mediated follicular helper T cells suppression.
Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates.
Phosphotyrosine 39 alpha-synuclein is a potential disease indicator for Parkinson disease and related alpha-synucleinopathies.
Study suggests histones as prime candidates for one of the nuclear proaggregant factors involved in the formation of transmissible alpha-synuclein aggregates during neuron apoptosis.
Study provides evidence that phosphorylated alpha-synuclein deposition is present in dermal nerve fibers in a subgroup of patients suffering from REM (show REM1 ELISA Kits) sleep behavior disorder, presumably representing prodromal Parkinson's disease.
This review describes the major findings supporting the occurrence of alpha-synuclein pathology propagation in Parkinson's disease and discusses how this phenomenon could induce or contribute to synaptic injury and degeneration. [Review]
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 ELISA Kits) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein