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SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. Additionally we are shipping SNCAIP Antibodies (55) and SNCAIP Proteins (5) and many more products for this protein.
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Differential expression of synphilin-1 isoforms (and alpha-synuclein (show SNCA ELISA Kits) and parkin (show PARK2 ELISA Kits)) was found in multiple system atrophy brains compared to control brain.
Synphilin-1 binds ATP, but not CTP (show CDS1 ELISA Kits).
Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.
Overexpression of SP1 (show PSG1 ELISA Kits) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (show PSG1 ELISA Kits) increased food intake but did not affect locomotor activity
Although serine-129 phosphorylation of alpha-synuclein (show SNCA ELISA Kits) facilitates tubulin polymerization promoting protein (TPPP (show Tppp ELISA Kits))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.
Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.
Neuronal survival factor MEF2D (show MEF2D ELISA Kits) is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein (show SNCA ELISA Kits) accumulation and aggregation.
Synphilin-1 inhibits alpha-synuclein (show SNCA ELISA Kits) degradation by the proteasome.
Knockdown of Herp (show HERPUD1 ELISA Kits) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.
Data show that periphilin (show PPHLN1 ELISA Kits) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (show PPHLN1 ELISA Kits) in PD.
This study shows that alpha-synuclein (show SNCA ELISA Kits) is present in cerebellar glutamatergic terminals.
These results suggest that increased levels of NUB1 (show NPM3 ELISA Kits) play a potential role in degradation of detergent-insoluble alpha-synuclein (show SNCA ELISA Kits) in vivo, although it is insufficient to degrade abnormal alpha-synuclein (show SNCA ELISA Kits) in Lewy body disease model mice.
SP1 (show SP1 ELISA Kits) results in a CCK (show CCK ELISA Kits) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice
TEM (show TNMD ELISA Kits) analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein (show SNCA ELISA Kits), suggesting the therapeutic potential of the small molecule in PD.
We exploited atomic force microscopy (AFM (show AFM ELISA Kits)) for the selective, nanoscale confinement of alpha-Synuclein (show SNCA ELISA Kits) on gold to study the early stages of alpha-Synuclein (show SNCA ELISA Kits) aggregation and the effect of small molecules, like dopamine, on the aggregation process.
Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.
Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.
Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein (show SNCA ELISA Kits) toxicity in vivo.
synphilin-1 has a role in skill learning and motor performance
expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.
synuclein, alpha interacting protein
, synuclein, alpha interacting protein (synphilin)
, alpha-synuclein-interacting protein
, synuclein alpha interacting protein
, synphilin-1 variant 1e