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Synuclein, alpha Interacting Protein Proteins (SNCAIP)

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. Additionally we are shipping SNCAIP Antibodies (55) and SNCAIP Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SNCAIP 9627 Q9Y6H5
Rat SNCAIP SNCAIP 307309  
SNCAIP 67847  
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Top SNCAIP Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SNCAIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Synuclein, alpha Interacting Protein (SNCAIP) Interaction Partners

Human Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin (show PARK2 Proteins)) was found in multiple system atrophy brains compared to control brain.

  2. Synphilin-1 binds ATP, but not CTP (show CDS1 Proteins).

  3. Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity.

  4. Overexpression of SP1 (show PSG1 Proteins) in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 (show PSG1 Proteins) increased food intake but did not affect locomotor activity

  5. Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP (show Tppp Proteins))-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation.

  6. Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease.

  7. Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation.

  8. Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.

  9. Knockdown of Herp (show HERPUD1 Proteins) gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition.

  10. Data show that periphilin (show PPHLN1 Proteins) displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin (show PPHLN1 Proteins) in PD.

Mouse (Murine) Synuclein, alpha Interacting Protein (SNCAIP) interaction partners

  1. This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals.

  2. These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice.

  3. SP1 (show SP1 Proteins) results in a CCK (show CCK Proteins) response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice

  4. TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD.

  5. We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process.

  6. Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments.

  7. Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics.

  8. Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo.

  9. synphilin-1 has a role in skill learning and motor performance

  10. expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease

SNCAIP Protein Profile

Protein Summary

This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of only two have been determined.

Gene names and symbols associated with SNCAIP

  • synuclein, alpha interacting protein (SNCAIP)
  • synuclein, alpha interacting protein (synphilin) (sncaip)
  • synuclein, alpha interacting protein (sncaip)
  • synuclein, alpha interacting protein (synphilin) (LOC100221074)
  • synuclein, alpha interacting protein (Sncaip)
  • synuclein, alpha interacting protein (synphilin) (Sncaip)
  • 2810407O15Rik protein
  • 4933427B05Rik protein
  • BB104594 protein
  • LOC100221074 protein
  • MGC88953 protein
  • SNCAIP protein
  • Sph1 protein
  • Syph1 protein

Protein level used designations for SNCAIP

synuclein, alpha interacting protein , synuclein, alpha interacting protein (synphilin) , synphilin-1-like , alpha-synuclein-interacting protein , synphilin-1 , synuclein alpha interacting protein , synphilin-1 variant 1e

GENE ID SPECIES
100063985 Equus caballus
448237 Xenopus (Silurana) tropicalis
700372 Macaca mulatta
462021 Pan troglodytes
100406168 Callithrix jacchus
100481199 Ailuropoda melanoleuca
100559476 Anolis carolinensis
100221074 Taeniopygia guttata
9627 Homo sapiens
307309 Rattus norvegicus
426796 Gallus gallus
100720184 Cavia porcellus
67847 Mus musculus
481479 Canis lupus familiaris
100049698 Sus scrofa
540156 Bos taurus
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