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anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Antibodies

TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Additionally we are shipping TIGIT Proteins (23) and TIGIT Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TIGIT 201633 Q495A1
TIGIT 100043314  
TIGIT 363784  
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Top anti-TIGIT Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TIGIT AntibodyTitration: 1.0 µg/mL  Positive Control: HepG2 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Mouse PE ELISA (Capture) 100 μg Log in to see 10 to 12 Days
$309.81
Details
Mouse Mouse APC ELISA (Detection), ELISPOT (Detection) 100 μg Log in to see 10 to 12 Days
$309.81
Details
Mouse Mouse Un-conjugated ICFC 500 μg Log in to see 10 to 12 Days
$320.68
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$422.40
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$435.60
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$459.80
Details
Human Rabbit FITC WB   100 μg Log in to see 8 to 10 Days
$625.17
Details
Mouse Rabbit Biotin ELISA, WB   100 μg Log in to see 8 to 10 Days
$698.50
Details
Mouse Rabbit FITC WB   100 μg Log in to see 8 to 10 Days
$742.50
Details

TIGIT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Top referenced anti-TIGIT Antibodies

  1. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ICFC - ABIN2665414 : Stanietsky, Simic, Arapovic, Toporik, Levy, Novik, Levine, Beiman, Dassa, Achdout, Stern-Ginossar, Tsukerman, Jonjic, Mandelboim: The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 references for ABIN2665414

  2. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ELISA (Detection), ELISPOT (Detection) - ABIN2658413 : Levin, Taft, Brandt, Bucher, Howard, Chadwick, Johnston, Hammond, Bontadelli, Ardourel, Hebb, Wolf, Bukowski, Rixon, Kuijper, Ostrander, West, Bilsborough, Fox, Gao, Xu, Ramsdell, Blazar, Lewis: Vstm3 is a member of the CD28 family and an important modulator of T-cell function. in European journal of immunology 2011 (PubMed)
    Show all 3 references for ABIN2658413

  3. Mouse (Murine) Monoclonal TIGIT Primary Antibody for ELISA (Capture) - ABIN2662886 : Yu, Harden, Gonzalez, Francesco, Chiang, Irving, Tom, Ivelja, Refino, Clark, Eaton, Grogan: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. in Nature immunology 2008 (PubMed)
    Show all 3 references for ABIN2662886

More Antibodies against TIGIT Interaction Partners

Human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.

  2. implying that TIGIT exerts immunosuppressive effects by competing with DNAM-1 (show CD226 Antibodies) for the same ligand, CD155 (show PVR Antibodies)

  3. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells

  4. This study shows that HBZ (show HBZ Antibodies)-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favorable to human T-cell leukemia virus type 1.

  5. a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.

  6. Human regulatory T cells expressing the receptors TIGIT and CD226 (show CD226 Antibodies) display widely divergent phenotypes in regard to expansion and activation.

  7. TIGIT and PD-1 (show PDCD1 Antibodies) blockade additively increased proliferation, cytokine production, and degranulation of tumor-antigen-specific CD8 (show CD8A Antibodies) T cells and CD8 (show CD8A Antibodies) TILs. TIGIT and PD-1 (show PDCD1 Antibodies) regulate the expansion and function of these T cells in melanoma.

  8. the TIGIT/FCRL3 (show FCRL3 Antibodies) combination allows reliable identification of Helios (show ZNFN1A2 Antibodies)(+) Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.

  9. The results identify a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT.

  10. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 Antibodies) function when disrupting its homodimerization.

Mouse (Murine) T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. TIGIT negatively regulates inflammation by altering macrophage phenotype.

  2. TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (show CD8A Antibodies)+ T cells. TIGIT+ Tregs upregulated TIM-3 (show HAVCR2 Antibodies) expression in tumor tissue. TIM-3 (show HAVCR2 Antibodies) and TIGIT synergized to suppress antitumor immune responses.

  3. TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.

  4. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 Antibodies) function when disrupting its homodimerization.

  5. TIGIT/PVR (show PVRL2 Antibodies) ligation signaling mediates suppression of IFN-gamma (show IFNG Antibodies) production via the NF-kappaB (show NFKB1 Antibodies) pathway.

  6. expressed on a Treg cell subset that selectively suppresses Th1 (show HAND1 Antibodies) and Th17 cells but not Th2 cells

  7. found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner

  8. findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (show PVRL2 Antibodies) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities

  9. animals deficient in Vstm3 are more sensitive to autoimmune challenges indicating that this new member of the CD28 (show CD28 Antibodies) family is an important regulator of T-cell responses

  10. TIGIT can act directly on T cells by attenuating T cell receptor-driven activation signals; loss of TIGIT results in hyperproliferative T cell responses and increased susceptibility to autoimmunity.

TIGIT Antigen Profile

Protein Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Gene names and symbols associated with TIGIT

  • T cell immunoreceptor with Ig and ITIM domains (TIGIT) antibody
  • T cell immunoreceptor with Ig and ITIM domains (Tigit) antibody
  • ENSMUSG00000071552 antibody
  • RGD1563191 antibody
  • VSIG9 antibody
  • Vstm3 antibody
  • WUCAM antibody

Protein level used designations for TIGIT

T-cell immunoreceptor with Ig and ITIM domains , V-set and immunoglobulin domain containing 9 , V-set and immunoglobulin domain-containing protein 9 , V-set and transmembrane domain containing 3 , V-set and transmembrane domain-containing protein 3 , Washington University cell adhesion molecule

GENE ID SPECIES
201633 Homo sapiens
100043314 Mus musculus
363784 Rattus norvegicus
Selected quality suppliers for anti-TIGIT (TIGIT) Antibodies
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