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TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Additionally we are shipping TIGIT Antibodies (37) and TIGIT Proteins (23) and many more products for this protein.
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TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.
implying that TIGIT exerts immunosuppressive effects by competing with DNAM-1 (show CD226 ELISA Kits) for the same ligand, CD155 (show PVR ELISA Kits)
These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells
This study shows that HBZ (show HBZ ELISA Kits)-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favorable to human T-cell leukemia virus type 1.
a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.
Human regulatory T cells expressing the receptors TIGIT and CD226 (show CD226 ELISA Kits) display widely divergent phenotypes in regard to expansion and activation.
TIGIT and PD-1 (show PDCD1 ELISA Kits) blockade additively increased proliferation, cytokine production, and degranulation of tumor-antigen-specific CD8 (show CD8A ELISA Kits) T cells and CD8 (show CD8A ELISA Kits) TILs. TIGIT and PD-1 (show PDCD1 ELISA Kits) regulate the expansion and function of these T cells in melanoma.
the TIGIT/FCRL3 (show FCRL3 ELISA Kits) combination allows reliable identification of Helios (show ZNFN1A2 ELISA Kits)(+) Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.
The results identify a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT.
Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 ELISA Kits) function when disrupting its homodimerization.
TIGIT negatively regulates inflammation by altering macrophage phenotype.
TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (show CD8A ELISA Kits)+ T cells. TIGIT+ Tregs upregulated TIM-3 (show HAVCR2 ELISA Kits) expression in tumor tissue. TIM-3 (show HAVCR2 ELISA Kits) and TIGIT synergized to suppress antitumor immune responses.
TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.
TIGIT/PVR (show PVRL2 ELISA Kits) ligation signaling mediates suppression of IFN-gamma (show IFNG ELISA Kits) production via the NF-kappaB (show NFKB1 ELISA Kits) pathway.
expressed on a Treg cell subset that selectively suppresses Th1 (show HAND1 ELISA Kits) and Th17 cells but not Th2 cells
found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner
findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (show PVRL2 ELISA Kits) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities
animals deficient in Vstm3 are more sensitive to autoimmune challenges indicating that this new member of the CD28 (show CD28 ELISA Kits) family is an important regulator of T-cell responses
TIGIT can act directly on T cells by attenuating T cell receptor-driven activation signals; loss of TIGIT results in hyperproliferative T cell responses and increased susceptibility to autoimmunity.
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
T-cell immunoreceptor with Ig and ITIM domains
, V-set and immunoglobulin domain containing 9
, V-set and immunoglobulin domain-containing protein 9
, V-set and transmembrane domain containing 3
, V-set and transmembrane domain-containing protein 3
, Washington University cell adhesion molecule