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TBX19 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping T-Box 19 Antibodies (15) and many more products for this protein.
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Identification of nine new TPIT mutations in a large series of congenital isolated ACTH (show POMC Proteins)-deficiency patients.
TPIT is identified as a target autoantigen in 10.5% of patients with lymphocytic hypophysitis.
The coordinate expression of Etv1 (show ETV1 Proteins) with POMC (show POMC Proteins) cell differentiation and its interaction with the highly cell-restricted Tpit factor indicate that Etv1 (show ETV1 Proteins) participates in a combinatorial code for pituitary cell-specific gene expression.
Review. Association of 2 mutations with an ACTH (show POMC Proteins) deficiency is consistent with the role of tbx19 in differentiation of POMC (show POMC Proteins) cells.
TPIT has a role in expression of the pro-opiomelanocortin (show POMC Proteins) gene and terminal differentiation of the pituitary corticotroph lineage, and its mutation causes early onset pituitary ACTH (show POMC Proteins) deficiency
Tpit, along with NGFI-B (show NR4A1 Proteins) and SRC-2 (show NCOA2 Proteins), is part of a transcription regulatory complex assembled on the POMC (show POMC Proteins) promoter in response to hormonal stimulation.
mutations in the TPIT gene, a T-box factor selectively expressed in developing corticotroph cells, have been found in cases of early-onset isolated ACTH (show POMC Proteins) deficiency
TPIT gene mutations is the principal molecular cause of neonatal congenital isolated ACTH (show POMC Proteins) deficiency
We report largest series of congenital ACTH (show POMC Proteins) deficiency and demonstrate molecular mechanism involves Tpit in majority of cases.
Overtransmission of a haplotype GAC (show GLS Proteins) at the TBX19 locus was associated with increased angry/hostility scores among suicide attempters.
Tpit has a role as a negative regulator of gonadotroph differentiation in developing mouse
Tpit and NeuroD1 (show NEUROD1 Proteins) are not essential for early corticotroph commitment. There are different levels of control for commitment of POMC (show POMC Proteins) lineages compared to cell survival or to cell-specific transcription of POMC (show POMC Proteins).
the M86R TPIT mutation is defining an important surface of the T domain for multiple protein interactions and for transcription
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure.
, T-box transcription factor TBX19-like
, T-box factor, pituitary
, T-box protein 19
, T-box transcription factor TBX19
, TBS 19
, T-box containing protein
, T-box-containing protein TBXT
, T-box transcription factor 19