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TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping TBX3 Antibodies (95) and TBX3 Kits (23) and many more products for this protein.
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identified two different TBX3 alleles causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 TBX3 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication
this new molecular-grade based on the combination of TBX2 (show TBX2 Proteins) and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Paracrine WNT (show WNT2 Proteins) signaling is stimulated by estrogen and progesterone, while autocrine WNT (show WNT2 Proteins) signaling is induced by the embryonic T-box transcription factor TBX3
Overexpression of Tbx3 is associated with pancreatic carcinoma.
Data show that the down-regulation of T-box transcription factor TBX2 (show TBX2 Proteins) by transforming growth factor beta I (TGF-beta1 (show TGFB1 Proteins)) is mediated by T-box transcription factor TBX3.
Polymorphisms in several genes involved in the Wnt (show WNT2 Proteins) signaling pathway were associated with hepatic fibrosis or inflammation risk in HCV-infected males.
TBX3 gene variants may contribute to indirect inguinal hernia as a rare risk factor by reducing TBX3 levels
An enhancement in TBX3 protein expression both in glomerular and tubular regions.
The pleiotropic effects of TBX3 mutations in humans and mice likely result from disrupting at least two molecular functions of this protein: transcriptional regulation and pre-mRNA splicing.
TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
TBX3 plays a pivotal role in mediating the antiproliferative and promigratory role of TGF-beta1 (show TGFB1 Proteins) in breast epithelial cells and skin keratinocytes.
Low TBX3 levels are associated with reduced pluripotency for embryonic stem cells, resembling the more mature epiblast.
miR (show MLXIP Proteins)-93 controls Tbx3 expression, thereby limiting self-renewal in early adipocyte precursors.
In-depth transcriptome analysis of this mESC state reveals Dppa3 (show DPPA3 Proteins) as a direct downstream target of Tbx3.We show that Tbx3, a downstream target of Wnt (show WNT2 Proteins) signaling, fine tunes these divergent roles of Wnt (show WNT2 Proteins) signaling in mESCs
Hoxc8 (show HOXC8 Proteins) initiates an ectopic mammary program by regulating Fgf10 (show FGF10 Proteins) and Tbx3 expression and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
Tbx3 can activate Zscan4 (show ZSCAN4 Proteins)(+)/2C state by negative regulation of DNA methylation (show HELLS Proteins) at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.
Tbx3 is important for the generation of hormone-sensing cells.
Taken together, we define further facets of TBX3 actions and map TBX3 as an upstream regulator of the mesendoderm transcriptional program during gastrulation.
The Tbx3 locus forms a CTCF (show CTCF Proteins)-independent autonomous regulatory domain with multiple combinatorial regulatory elements that control the precise pattern of Tbx3 in the cardiac conduction system.
Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1 (show CSF1 Proteins)-dependent expression of JDP2 (show JDP2 Proteins).
results not only reveal the essential roles of Tbx3 and Tbx3+2a in pluripotency maintaining, but also point out the different mechanistic modes between these two isoforms
Results suggested that Tbx3 and Nr5alpha2 may have vital roles in pluripotent stem cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms\; however, the full length nature of one variant has not been determined.
, transcription factor Tbx3
, T-box 3 protein
, T-box 3 (ulnar mammary syndrome)
, T-box transcription factor TBX3-like
, t-box transcription factor TBX3-like
, T-box protein 3
, T-box transcription factor TBX3
, bladder cancer related protein XHL
, T-Box protein 3