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T-Box 5 (TBX5) ELISA Kits

TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping T-Box 5 Antibodies (77) and T-Box 5 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human TBX5 TBX5 6910 Q99593
Anti-Mouse TBX5 TBX5 21388 P70326
Anti-Rat TBX5 TBX5 304514 Q5I2P1
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More ELISA Kits for T-Box 5 Interaction Partners

Xenopus laevis T-Box 5 (TBX5) interaction partners

  1. we show TBX5 and TBX20 (show TBX20 ELISA Kits) can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 5 (TBX5) interaction partners

  1. report on the association between a TBX5 lossoffunction mutation and increased susceptibility to atrial fibrillation

  2. Whole-genome microarray mRNA-expression profiles of myofibroblasts and skin fibroblasts revealed four additional genes that are significantly differentially expressed in these two cell types: NKX2-3 and LRRC17 (show LRRC17 ELISA Kits) in myofibroblasts and SHOX2 (show SHOX2 ELISA Kits) and TBX5 in skin fibroblasts

  3. The Barrett-associated variants at GDF7 (show GDF7 ELISA Kits) and TBX5 also increase esophageal adenocarcinoma risk.

  4. These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 (show TBX3 ELISA Kits) and TBX5, and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1 (show LMBR1 ELISA Kits)

  5. provide both genetic and functional evidence to support the contribution of TBX5 gene in the pathogenesis of Atrial fibrillation

  6. In summary, our study implicated a gene network involving Tbx5, Osr1 (show OXSR1 ELISA Kits) and Pcsk6 (show PCSK6 ELISA Kits) interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny.

  7. The findings expand the mutational spectrum of TBX5 linked to Atrial fibrillation (AF), and provide new evidence that dysfunctional TBX5 may contribute to lone AF.

  8. TBX5 microdeletion with microinsertion was detected in patient with Holt-Oram syndrome.

  9. The crystal structure of cardiac TBX5 protein includes the N-terminal and DNA binding domains, which mediate intermolecular interactions.

  10. Exome analysis revealed the splice mutation (c.148-1G>C) in TBX5 gene showing that haploinsufficiency of TBX5 protein caused the symptoms of the patients with Holt-Oram syndrome.

Mouse (Murine) T-Box 5 (TBX5) interaction partners

  1. Data show that three transcriptional factors Gata4 (show GATA4 ELISA Kits), Mef2c (show MEF2C ELISA Kits), and Tbx5 (abbreviated as GMT (show GAMT ELISA Kits)) significantly improved murine embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) differentiated into cardiomyocytes.

  2. defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

  3. Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5 (show NKX2-5 ELISA Kits), and the zinc finger TF GATA4 (show GATA4 ELISA Kits) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  4. Tbx5 and Osr1 (show OSR1 ELISA Kits) interact to regulate posterior second heart field cell cycle progression for cardiac septation.

  5. Haploinsufficiency of Tbx5 and trisomy affects alignment of the aorta and this effect may stem from deviations from normal left-right patterning in the heart; study unveiled a previously unknown interaction between the Tbx5 gene and trisomy, suggesting a connection between Tbx5 and trisomic genes important during heart development.

  6. These findings elucidate mechanisms regulating the commitment of mesodermal cells in the early embryo and identify the Tbx5 cardiac transcriptome.

  7. these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz (show MYST3 ELISA Kits) germline mutant mice is due to loss of MOZ (show MYST3 ELISA Kits)-dependant activation of mesodermal Tbx1 (show TBX1 ELISA Kits) and Tbx5 expression.

  8. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 (show NKX2-5 ELISA Kits) and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 (show NKX2-5 ELISA Kits) and Tbx5 transcriptional activity.

  9. Our findings implicate Foxf genes in atrioventricular septation, describe the molecular underpinnings of the genetic interaction between Hedgehog signaling and Tbx5, and establish a molecular model for the selection of the SHF gene regulatory network

  10. Disruption of myocardial Gata4 (show GATA4 ELISA Kits) and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.

Zebrafish T-Box 5 (TBX5) interaction partners

  1. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility.

  2. Results show that cul4a (show CUL4A ELISA Kits) but not cul4b (show CUL4B ELISA Kits) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

  3. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development.

  4. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis

  5. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos

  6. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20 (show TBX20 ELISA Kits), and has2 (show HAS2 ELISA Kits) in the heart

  7. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development.

  8. Pdlim7 (show PDLIM7 ELISA Kits)/Tbx5 interactions affect the expression of Tbx5 target genes nppa (show NPPA ELISA Kits) and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects.

  9. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

  10. overexpression of hrT (show TBX20 ELISA Kits) causes a significant downregulation of tbx5, indicating that one key role of hrT (show TBX20 ELISA Kits) is to regulate the levels of tbx5

T-Box 5 (TBX5) Antigen Profile

Antigen Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with T-Box 5 (TBX5) ELISA Kits

  • T-box 5 (TBX5) antibody
  • T-box 5 (tbx5) antibody
  • T-box 5 (LOC100356836) antibody
  • T-box 5 (tbx5-b) antibody
  • T-box 5 (Tbx5) antibody
  • T-box 5a (tbx5a) antibody
  • HOS antibody
  • tbx-5 antibody
  • tbx5 antibody
  • tbx5.1 antibody
  • xtbx-5 antibody
  • xtbx5 antibody
  • zf-tbx5 antibody
  • zTbx5 antibody

Protein level used designations for T-Box 5 (TBX5) ELISA Kits

T-box 5 , T-box protein 5 , T-box transcription factor 5 , T-box transcription factor TBX5 , T-box transcription factor TBX5-like , t-box transcription factor TBX5-like , T-box gene 5 , T-box gene 5.1 , T-box transcription factor TBX5-A , etID310031.5 , heartstrings , hst , zftbx5a

452276 Pan troglodytes
619589 Xenopus (Silurana) tropicalis
713550 Macaca mulatta
100018880 Monodelphis domestica
100356836 Oryctolagus cuniculus
100397050 Callithrix jacchus
100451005 Pongo abelii
100478001 Ailuropoda melanoleuca
100529166 Oryzias latipes
373738 Xenopus laevis
373988 Gallus gallus
6910 Homo sapiens
491447 Canis lupus familiaris
21388 Mus musculus
304514 Rattus norvegicus
532970 Bos taurus
30071 Danio rerio
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