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anti-T-Cell Acute Lymphocytic Leukemia 1 (TAL1) Antibodies

Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Additionally we are shipping TAL1 Proteins (6) and TAL1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TAL1 21349 P22091
TAL1 6886 P17542
TAL1 313507  
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Top anti-TAL1 Antibodies at antibodies-online.com

Showing 10 out of 140 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TAL1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human brain Host: Rabbit  Target Name: TAL1  Sample Tissue: Human Fetal Liver  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-TAL1 Antibody Titration: 1.25ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-TAL1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells treated with PMA 125ng/ml 30', using TAL-1 (Phospho-Ser122) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-TAL1 Antibody (T90) (ABIN389232) in Jurkat cell line lysates (35 µg/lane). TAL1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, treated with PMA 125ng/ml 30', using TAL-1 (Ab-122) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

TAL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TAL1 Antibodies

  1. Human Polyclonal TAL1 Primary Antibody for EIA, WB - ABIN357907 : Kassouf, Chagraoui, Vyas, Porcher: Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. in Blood 2008 (PubMed)
    Show all 3 references for ABIN357907

  2. Human Polyclonal TAL1 Primary Antibody for WB - ABIN389232 : Terme, Wencker, Favre-Bonvin, Bex, Gazzolo, Duc Dodon, Jalinot: Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1. in Journal of virology 2008 (PubMed)
    Show all 3 references for ABIN389232

  3. Dog (Canine) Polyclonal TAL1 Primary Antibody for WB - ABIN2792542 : Le Clech, Chalhoub, Dohet, Roure, Fichelson, Moreau-Gachelin, Mathieu: PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity. in Journal of molecular biology 2005 (PubMed)
    Show all 2 references for ABIN2792542

  4. Cow (Bovine) Polyclonal TAL1 Primary Antibody for WB - ABIN2777291 : Zhang, Swanson: V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN2777291

  5. Human Polyclonal TAL1 Primary Antibody for ELISA, WB - ABIN1533194 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

  6. Cow (Bovine) Polyclonal TAL1 Primary Antibody for IHC, WB - ABIN2792541 : Ravet, Reynaud, Titeux, Izac, Fichelson, Roméo, Dubart-Kupperschmitt, Pflumio: Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. in Blood 2004 (PubMed)

More Antibodies against TAL1 Interaction Partners

Mouse (Murine) T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. TAL1 and GATA1 (show GATA1 Antibodies) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations

  2. SCL-LMO1 (show LMO1 Antibodies) upregulated a stem cell gene signature in DN3 thymocytes.

  3. TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (show GATA1 Antibodies) is produced abundantly.

  4. Ectopic Runx1 (show RUNX1 Antibodies) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

  5. Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice

  6. Only Scl but not Map17 (show PDZK1IP1 Antibodies) could rescue the Scl(Delta40/Delta40) ES phenotype.

  7. Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (show NOTCH1 Antibodies) pathways during the embryonic endothelial-to-hematopoietic transition.

  8. a novel role for GATA-4 (show GATA4 Antibodies) and TAL1 to affect skeletal myogenic differentiation and EPO (show EPO Antibodies) response via cross-talk with Sirt1 (show SIRT1 Antibodies).

  9. Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac (show ADCY10 Antibodies) vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice.

  10. Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.

Human T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Antibodies), FLI1 (show FLI1 Antibodies) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.

  2. analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter

  3. a successful induction of gamma-globin (show HBG1 Antibodies) includes a reduction in BCL11A (show BCL11A Antibodies), KLF1 (show KLF1 Antibodies) and TAL1 expression.

  4. SCL (show KRT7 Antibodies)-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.

  5. These results indicate that KLF1 (show KLF1 Antibodies) plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Antibodies) and TAL1 occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping

  6. Scl (show KRT7 Antibodies) binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.

  7. SCL/TAL1 is located in the up-stream of MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway and partially regulates hematopoiesis by modulating the phosphorylation level of the key proteins in MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway.

  8. study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB (show MYB Antibodies) transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene (show RAB1A Antibodies); MYB (show MYB Antibodies) binds to this new site

  9. The results indicate that TAL1 plays a critical role in chromatin loop formation between the gamma-globin genes and locus control region, which is a critical step for the transcription of the gamma-globin genes.

  10. SIL (show PMEL Antibodies)-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.

Zebrafish T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. The latter data suggest that Stil (show STIL Antibodies) play a role in retina cell proliferation through the Shh (show SHH Antibodies) signal transduction pathway.

  2. Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.

  3. Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (show FUT1 Antibodies) development.

  4. Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation

  5. Ets1-related protein (show ETV2 Antibodies) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.

  6. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (show LMO2 Antibodies)-induced haemangioblasts differentiate into endothelial cells

  7. Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.

  8. scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium

  9. Scl participates in multiple processes requiring different levels and functions

  10. While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.

TAL1 Antigen Profile

Protein Summary

Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.

Gene names and symbols associated with TAL1

  • T cell acute lymphocytic leukemia 1 (Tal1) antibody
  • T-cell acute lymphocytic leukemia 1 (TAL1) antibody
  • T-cell acute lymphocytic leukemia 1 (Tal1) antibody
  • T-cell acute lymphocytic leukemia 1 (tal1) antibody
  • bHLHa17 antibody
  • scl antibody
  • SCL-alpha antibody
  • SCL-beta antibody
  • SCL/tal-1 antibody
  • scl/tal1 antibody
  • tal-1 antibody
  • tcl5 antibody
  • zgc:85605 antibody

Protein level used designations for TAL1

T-cell acute lymphocytic leukemia 1 , T-cell acute lymphocytic leukemia protein 1 homolog , stem cell protein , T-cell acute lymphocytic leukemia protein 1 , T-cell leukemia/lymphoma protein 5 , class A basic helix-loop-helix protein 17 , tal-1 product , TAL-1 , stem cell leukaemia , stem cell leukemia protein SCL , xSCL , Avian SCL , stem-cell leukemia hematopoietic transcription factor , transcription factor , zSCL

GENE ID SPECIES
21349 Mus musculus
6886 Homo sapiens
610331 Canis lupus familiaris
518657 Bos taurus
313507 Rattus norvegicus
398028 Xenopus laevis
396298 Gallus gallus
30766 Danio rerio
Selected quality suppliers for anti-TAL1 (TAL1) Antibodies
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