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Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Additionally we are shipping TAL1 Proteins (6) and TAL1 Kits (4) and many more products for this protein.
Showing 10 out of 182 products:
Human Polyclonal TAL1 Primary Antibody for EIA, WB - ABIN357907
Kassouf, Chagraoui, Vyas, Porcher: Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. in Blood 2008
Show all 3 references for ABIN357907
Human Polyclonal TAL1 Primary Antibody for WB - ABIN389232
Terme, Wencker, Favre-Bonvin, Bex, Gazzolo, Duc Dodon, Jalinot: Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1. in Journal of virology 2008
Show all 3 references for ABIN389232
Cow (Bovine) Polyclonal TAL1 Primary Antibody for WB - ABIN2777291
Zhang, Swanson: V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies. in The Journal of biological chemistry 2008
Show all 2 references for ABIN2777291
Dog (Canine) Polyclonal TAL1 Primary Antibody for WB - ABIN2792542
Le Clech, Chalhoub, Dohet, Roure, Fichelson, Moreau-Gachelin, Mathieu: PU.1/Spi-1 binds to the human TAL-1 silencer to mediate its activity. in Journal of molecular biology 2005
Show all 2 references for ABIN2792542
Human Polyclonal TAL1 Primary Antibody for ELISA, WB - ABIN1533194
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Cow (Bovine) Polyclonal TAL1 Primary Antibody for IHC, WB - ABIN2792541
Ravet, Reynaud, Titeux, Izac, Fichelson, Roméo, Dubart-Kupperschmitt, Pflumio: Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. in Blood 2004
TAL1 and GATA1 (show GATA1 Antibodies) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
SCL-LMO1 (show LMO1 Antibodies) upregulated a stem cell gene signature in DN3 thymocytes.
TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (show GATA1 Antibodies) is produced abundantly.
Ectopic Runx1 (show RUNX1 Antibodies) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice
Only Scl but not Map17 (show PDZK1IP1 Antibodies) could rescue the Scl(Delta40/Delta40) ES phenotype.
Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (show NOTCH1 Antibodies) pathways during the embryonic endothelial-to-hematopoietic transition.
a novel role for GATA-4 (show GATA4 Antibodies) and TAL1 to affect skeletal myogenic differentiation and EPO (show EPO Antibodies) response via cross-talk with Sirt1 (show SIRT1 Antibodies).
Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac (show ADCY10 Antibodies) vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice.
Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.
Upregulation of TAL1 is associated with T-cell acute lymphoblastic leukemia.
Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Antibodies), FLI1 (show FLI1 Antibodies) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
a successful induction of gamma-globin (show HBG1 Antibodies) includes a reduction in BCL11A (show BCL11A Antibodies), KLF1 (show KLF1 Antibodies) and TAL1 expression.
SCL (show KRT7 Antibodies)-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.
These results indicate that KLF1 (show KLF1 Antibodies) plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Antibodies) and TAL1 occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping
Scl (show KRT7 Antibodies) binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.
SCL/TAL1 is located in the up-stream of MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway and partially regulates hematopoiesis by modulating the phosphorylation level of the key proteins in MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway.
study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB (show MYB Antibodies) transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene (show RAB1A Antibodies); MYB (show MYB Antibodies) binds to this new site
The results indicate that TAL1 plays a critical role in chromatin loop formation between the gamma-globin genes and locus control region, which is a critical step for the transcription of the gamma-globin genes.
The latter data suggest that Stil (show STIL Antibodies) play a role in retina cell proliferation through the Shh (show SHH Antibodies) signal transduction pathway.
Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.
Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (show FUT1 Antibodies) development.
Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation
Ets1-related protein (show ETV2 Antibodies) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (show LMO2 Antibodies)-induced haemangioblasts differentiate into endothelial cells
Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.
scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium
Scl participates in multiple processes requiring different levels and functions
While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.
Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
T-cell acute lymphocytic leukemia 1
, T-cell acute lymphocytic leukemia protein 1 homolog
, stem cell protein
, T-cell acute lymphocytic leukemia protein 1
, T-cell leukemia/lymphoma protein 5
, class A basic helix-loop-helix protein 17
, tal-1 product
, stem cell leukaemia
, stem cell leukemia protein SCL
, Avian SCL
, stem-cell leukemia hematopoietic transcription factor
, transcription factor