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Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Additionally we are shipping TIMD4 Proteins (7) and TIMD4 Kits (6) and many more products for this protein.
Showing 10 out of 101 products:
Human Polyclonal TIMD4 Primary Antibody for WB - ABIN1881886
Dorfman, Hornick, Shahsafaei, Freeman: The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. in Human pathology 2010
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Mouse (Murine) Monoclonal TIMD4 Primary Antibody for FACS - ABIN2663932
Rodriguez-Manzanet, Meyers, Balasubramanian, Slavik, Kassam, Dardalhon, Greenfield, Anderson, Sobel, Hafler, Strom, Kuchroo: TIM-4 expressed on APCs induces T cell expansion and survival. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Mouse (Murine) Monoclonal TIMD4 Primary Antibody for IF, ICFC - ABIN2658022
Kuchroo, Dardalhon, Xiao, Anderson: New roles for TIM family members in immune regulation. in Nature reviews. Immunology 2008
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Human Polyclonal TIMD4 Primary Antibody for EIA, IF - ABIN500917
Meyers, Sabatos, Chakravarti, Kuchroo: The TIM gene family regulates autoimmune and allergic diseases. in Trends in molecular medicine 2005
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Mouse (Murine) Monoclonal TIMD4 Primary Antibody for FACS, IP - ABIN2663930
Miyanishi, Tada, Koike, Uchiyama, Kitamura, Nagata: Identification of Tim4 as a phosphatidylserine receptor. in Nature 2007
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Human Polyclonal TIMD4 Primary Antibody for WB - ABIN318767
Meyers, Chakravarti, Schlesinger, Illes, Waldner, Umetsu, Kenny, Zheng, Umetsu, DeKruyff, Strom, Kuchroo: TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. in Nature immunology 2005
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STAT6 (show STAT6 Antibodies) mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 (show NOTCH1 Antibodies) and STAT6 (show STAT6 Antibodies) mediate the microbial product CT-induced TIM4 expression in DCs.
Blockade of Tim-4 aggravates atherosclerosis in LDL receptor (show LDLR Antibodies) knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells.
results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases
TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries.
M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death
intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury
TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells.
Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice.
In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level.
the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK (show MERTK Antibodies)-mediated cell engulfment
Data indicate that T cell immunoglobulin and mucin domain containing 4 (TIM-4) contributes, at least in part, to the pathogenesis of type 2 diabetes mellitus (T2D), possibly by regulating interleukin-1beta (IL-1beta (show IL1B Antibodies)).
TIM4 binds TIM3 (show HAVCR2 Antibodies) on the surface of polarized Th1 (show TH1L Antibodies) cells to induce Th1 (show TH1L Antibodies) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
TIM-4 rs7700944 and not TIM-1 (show ARHGEF5 Antibodies) rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian.
Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 (show ITGAV Antibodies) through its RGD motif.
Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls.
Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis
Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 (show ANGPTL3 Antibodies) protein), TIMD4 (T cell immunoglobulin mucin-4 (show MUC4 Antibodies)), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW]
TIM4 expression is promoted by Cockroach allergen Bla (show LACTB Antibodies) g 7 in dendritic cells leading to Th2 polarization
TIM-1 (show ARHGEF5 Antibodies) and TIM-4 are novel targets for ADAM10 (show ADAM10 Antibodies)- and ADAM17 (show ADAM17 Antibodies)-mediated ectodomain shedding.
FG-CC' siRNA blocking interaction of Tim-1 (show ARHGEF5 Antibodies) and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer.
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
T-cell immunoglobulin and mucin domain containing 4
, T-cell immunoglobulin and mucin domain-containing protein 4
, T-cell membrane protein 4
, spleen, mucin-containing, knockout of lymphotoxin protein