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T-Cell Immunoglobulin and Mucin Domain Containing 4 Proteins (TIMD4)

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Additionally we are shipping TIMD4 Antibodies (93) and TIMD4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TIMD4 TIMD4 497891  
TIMD4 276891 Q6U7R4
TIMD4 91937 Q96H15
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Top TIMD4 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TIMD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
,
Human , , ,
,

More Proteins for T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) Interaction Partners

Mouse (Murine) T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) interaction partners

  1. Blockade of Tim-4 aggravates atherosclerosis in LDL receptor (show LDLR Proteins) knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells.

  2. results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases

  3. TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries.

  4. M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death

  5. intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury

  6. TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells.

  7. Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice.

  8. In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level.

  9. the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK (show MERTK Proteins)-mediated cell engulfment

  10. Data suggest that trans-membrane (or T cell) immunoglobulin and mucin (show SLC13A2 Proteins) (TIM) molecules are expressed in embryonic hematopoietic tissues in chicken and mouse and that in fetal liver, TIM-4 is expressed by myeloid progenitor cells.

Human T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) interaction partners

  1. TIM-4 rs7700944 and not TIM-1 (show ARHGEF5 Proteins) rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian.

  2. Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 (show ITGAV Proteins) through its RGD motif.

  3. Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls.

  4. Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis

  5. Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 (show ANGPTL3 Proteins) protein), TIMD4 (T cell immunoglobulin mucin-4 (show MUC4 Proteins)), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW]

  6. TIM4 expression is promoted by Cockroach allergen Bla (show LACTB Proteins) g 7 in dendritic cells leading to Th2 polarization

  7. TIM-1 (show ARHGEF5 Proteins) and TIM-4 are novel targets for ADAM10 (show ADAM10 Proteins)- and ADAM17 (show ADAM17 Proteins)-mediated ectodomain shedding.

  8. FG-CC' siRNA blocking interaction of Tim-1 (show ARHGEF5 Proteins) and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer.

  9. There were four SNPs in the promoter region of TIM4 in asthma patients of Chinese Han population, which were in linkage disequilibrium.

  10. TIM-4 variant or a highly correlated nearby gene of the TIM-4 gene may play a critical role in the pathogenesis of rheumatoid arthritis in many ethnicities.

TIMD4 Protein Profile

Protein Summary

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

Gene names and symbols associated with TIMD4

  • T-cell immunoglobulin and mucin domain containing 4 (Timd4)
  • T-cell immunoglobulin and mucin domain containing 4 (TIMD4)
  • T-cell immunoglobulin and mucin domain containing 4 (timd4)
  • T cell immunoglobulin and mucin domain containing 4 (Timd4)
  • B430010N18Rik protein
  • MGC99322 protein
  • RGD1564516 protein
  • SMUCKLER protein
  • TIM-4 protein
  • TIM4 protein
  • TIMD4 protein

Protein level used designations for TIMD4

T-cell immunoglobulin and mucin domain containing 4 , T-cell immunoglobulin and mucin domain-containing protein 4 , T-cell membrane protein 4 , TIMD-4 , smuckler , spleen, mucin-containing, knockout of lymphotoxin protein , TIM-4

GENE ID SPECIES
497891 Rattus norvegicus
416250 Gallus gallus
447692 Xenopus laevis
462217 Pan troglodytes
489160 Canis lupus familiaris
507549 Bos taurus
100597340 Nomascus leucogenys
276891 Mus musculus
91937 Homo sapiens
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