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Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Additionally we are shipping TIMD4 Antibodies (93) and TIMD4 Kits (5) and many more products for this protein.
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Blockade of Tim-4 aggravates atherosclerosis in LDL receptor (show LDLR Proteins) knockout mice likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells.
results indicate that Tim-4 is involved in negative regulation of NO production in macrophages, suggesting the critical role of Tim-4 in immune related diseases
TIM-4 on dendritic cells plays a critical role in hepatic ischemia-reperfusion (IR) injury and may be an efficient target for the prevention of liver or other organ IR injuries.
M2-like TIM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allografts, but their influence is diminished by TIM-4-dependent programmed cell death
intrinsic macrophage-specific TIM-4 signaling has indispensable role in innate immunity-driven liver ischemia-reperfusion injury
TIM4 engages integrins as coreceptors to evoke the signal transduction needed to internalize PtdSer-bearing targets such as apoptotic cells.
Tim-4 expression was higher in Behcet's disease (BD) mice than that in BDN mice.
In addition to the known phosphatidylserine(PS) binding pocket, Tim4 has four weaker sites of interaction, making it sensitive to PS surface concentration in a manner capable of differential recognition on the basis of PS exposure level.
the engulfment of apoptotic cells by resident peritoneal macrophages proceeds in two steps: binding to Tim4, a PtdSer receptor, followed by MerTK (show MERTK Proteins)-mediated cell engulfment
Data suggest that trans-membrane (or T cell) immunoglobulin and mucin (show SLC13A2 Proteins) (TIM) molecules are expressed in embryonic hematopoietic tissues in chicken and mouse and that in fetal liver, TIM-4 is expressed by myeloid progenitor cells.
TIM-4 rs7700944 and not TIM-1 (show ARHGEF5 Proteins) rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian.
Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 (show ITGAV Proteins) through its RGD motif.
Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls.
Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis
Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 (show ANGPTL3 Proteins) protein), TIMD4 (T cell immunoglobulin mucin-4 (show MUC4 Proteins)), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW]
TIM4 expression is promoted by Cockroach allergen Bla (show LACTB Proteins) g 7 in dendritic cells leading to Th2 polarization
TIM-1 (show ARHGEF5 Proteins) and TIM-4 are novel targets for ADAM10 (show ADAM10 Proteins)- and ADAM17 (show ADAM17 Proteins)-mediated ectodomain shedding.
FG-CC' siRNA blocking interaction of Tim-1 (show ARHGEF5 Proteins) and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer.
There were four SNPs in the promoter region of TIM4 in asthma patients of Chinese Han population, which were in linkage disequilibrium.
TIM-4 variant or a highly correlated nearby gene of the TIM-4 gene may play a critical role in the pathogenesis of rheumatoid arthritis in many ethnicities.
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
T-cell immunoglobulin and mucin domain containing 4
, T-cell immunoglobulin and mucin domain-containing protein 4
, T-cell membrane protein 4
, spleen, mucin-containing, knockout of lymphotoxin protein