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TLX1 encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. Additionally we are shipping TLX1 Antibodies (40) and many more products for this protein.
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Tlx1(CreER-Venus) mice represent a new tool for lineage tracing and conditional gene manipulation of spleen mesenchymal cells during morphogenesis.
Hox11 genes are expressed in the connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of the zeugopod region throughout all stages of development.
Tlx1/3 and Ptf1a (show PTF1A Proteins), the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord
Results demonstrate that the transcriptional activity of HOX11 is regulated by phosphorylation of Thr247 in a cell cycle-specific manner and that this phosphorylation modulates the expression of the target gene, cyclin B1 (show CCNB1 Proteins).
Hox11 paralogous genes regulate wrist and ankle joint organization and are essential for establishing carpal and tarsal element boundary and maintaining their articulating surface tissue.
Seven conserved Cdx (show CDX1 Proteins) binding sites were found in the Hoxa 11 (show HOXA11 Proteins) promoter, suggesting regulatory sites.
dysregulated expression of a particular set of downstream target genes by DNA binding via the homeodomain is of central importance for leukemia initiation mediated by HOX11 homeodomain protein
results have shown that the Hox10 (show VSX2 Proteins) and Hox11 paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements
These studies establish a Pbx1 (show PBX1 Proteins)-Hox11-dependent genetic and transcriptional pathway in spleen ontogeny.
HOX11/TLX1 stem cells from the spleen of normal mice have been harvested to assist in both the treatment and cure at least two autoimmune diseases.
The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.
these results place TLX1 and TLX3 (show TLX3 Proteins) at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 (show RUNX1 Proteins) as a tumor-suppressor gene in T-ALL
The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 (show TLX3 Proteins) is due to binding of TLX1/TLX3 (show TLX3 Proteins) to ETS1 (show ETS1 Proteins).
Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression.
conclude that the TLX1/NOTCH (show NOTCH1 Proteins)/MYC (show MYC Proteins) network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH (show NOTCH1 Proteins)/MYC (show MYC Proteins) transcriptional network coregulates genes involved in T cell development
Transgenic expression of human TLX1 in mice induces T cell acute lymphoblastic leukemia with frequent deletions and mutations in Bcl11b.
co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.
A PBX2 (show PBX2 Proteins) Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells.
Hox11 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children.
Detrmination site by nested polymerase chain reaction the integration sites in TLX1-immortalized hematopoietic cell lines.
identification and expression patterns of three members of the zebrafish Tlx (show NR2E1 Proteins) family
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.
T-cell leukemia homeobox protein 1
, T-cell leukemia, homeobox 1
, homeobox TLX-1
, homeobox protein Hox-11
, T-cell leukemia/lymphoma protein 3
, homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
, proto-oncogene TCL-3
, homeobox protein 11