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T-Cell Leukemia Homeobox 2 Proteins (TLX2)

TLX2 is a member of an orphan homeobox-containing transcription factor family. Additionally we are shipping T-Cell Leukemia Homeobox 2 Antibodies (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TLX2 21909 Q61663
TLX2 3196 O43763
Rat TLX2 TLX2 680117  
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Top T-Cell Leukemia Homeobox 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

TLX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for T-Cell Leukemia Homeobox 2 (TLX2) Interaction Partners

Mouse (Murine) T-Cell Leukemia Homeobox 2 (TLX2) interaction partners

  1. These results suggest that high subsarcolemmal Ca2 (show CA2 Proteins)+ is required to ensure synchronous triggering with short spark latency in the absence of NCX (show SLC8A1 Proteins).

  2. Expression of the transgene by enteric neurons and penetrance of pseudo-obstruction in Hox11L1-null animals are influenced by one or more modifier genes, counterparts of which may play a similar role in human disease.

  3. Intestinal dysmotility in Hox11L1-null animals may not be a primary neural disorder.

  4. Alignment of sequences obtained from rat, human, and mouse indicates that putative regulatory elements of the Hox11L1 gene are conserved in rat, mice, and humans.

  5. Our study suggests that NKCC1 (show SLC12A2 Proteins) acting in concert with NCX (show SLC8A1 Proteins) causes a perturbation of Ca(m)(2+) homeostasis and mitochondrial dysfunction and cell death following in vitro ischemia.

  6. Ncx (show SLC8A1 Proteins) participates in normal developmental cell death of enteric neurons. Ncx (show SLC8A1 Proteins) may modulate, if not directly target, expression of the caspase-3 (show CASP3 Proteins) at the transcriptional level to participate in neuronal cell death in the enteric nervous system.

Human T-Cell Leukemia Homeobox 2 (TLX2) interaction partners

  1. NCX-TRPC channel interaction constitutes an important functional unit in receptor-mediated divalent calcium ion influx in neuronal cells.

  2. NCX is functionally expressed in developing ventricular human embryonic stem cell-derived ventricular cardiomyocytes and contributes to their excitation-contraction coupling.

  3. This paper describes sequencing and comparison of 5' flanking regions of the gene, and expression in several neuroblastoma (show ARHGEF16 Proteins) cell lines, in both mouse and human.

  4. TLX2 is an orphan homeodomain transcription factor whose expression is mainly associated with tissues derived from neural crest cells.

  5. Alignment of sequences obtained from rat, human, and mouse indicates that putative regulatory elements of the Hox11L1 gene are conserved in rat, mice, and humans.

  6. These results support the PHOX2B (show PHOX2B Proteins)-TLX2 promoter interaction, suggesting a physiological role in the transcription-factor cascade underlying the differentiation of neuronal lineages of the Autonomic Nervous System during human embryogenesis.

  7. Hox11L1 has a role in tumorigenesis in gastrointestinal stromal tumors

Zebrafish T-Cell Leukemia Homeobox 2 (TLX2) interaction partners

  1. identification and expression patterns of three members of the zebrafish Tlx (show NR2E1 Proteins) family

T-Cell Leukemia Homeobox 2 (TLX2) Protein Profile

Protein Summary

This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system\; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors.

Gene names and symbols associated with TLX2

  • T cell leukemia, homeobox 2 (Tlx2)
  • T-cell leukemia homeobox 2 (TLX2)
  • T-cell leukemia homeobox 2 (Tlx2)
  • T-cell leukemia, homeobox 2 (tlx2)
  • Enx protein
  • hox11l protein
  • Hox11L.1 protein
  • HOX11L1 protein
  • NCX protein
  • Ncx1 protein
  • Tlx-3a protein
  • Tlx1l1 protein
  • Tlx1l2 protein
  • tlx3a protein
  • tlxA protein

Protein level used designations for TLX2

PMUR10F , T-cell leukemia homeobox protein 2 , T-cell leukemia, homeobox 2 , enteric neuron homeobox protein , homeo box 11-like 1 , homeobox TLX-2 , homeobox protein Hox-11L1 , neural crest homeobox protein , T-cell leukemia, homeobox 3a

GENE ID SPECIES
21909 Mus musculus
3196 Homo sapiens
483102 Canis lupus familiaris
680117 Rattus norvegicus
539041 Bos taurus
170781 Danio rerio
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