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Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). Additionally we are shipping T-Cell Leukemia/lymphoma 1A Antibodies (77) and T-Cell Leukemia/lymphoma 1A Kits (2) and many more products for this protein.
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Human TCL1A Protein expressed in Escherichia coli (E. coli) - ABIN666894
Herling, Patel, Khalili, Schlette, Kobayashi, Medeiros, Jones: TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. in Leukemia 2006
Show all 2 references for ABIN666894
results indicate that decreased Cav-1 (show CAV1 Proteins) in Emu-TCL1 mice significantly delays the onset of CLL and decreases leukemic progression by inhibiting MAPK-Erk (show MAPK1 Proteins) signaling, suggesting a role for Cav-1 (show CAV1 Proteins) in the proliferation and progression of CLL
This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development.
Tcl1 expression downregulated a distinct group of genes, including Ndp52 (show CALCOCO2 Proteins), whose expression is very high in blastocysts but reduced in the primitive ectoderm.
Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI (show TNFRSF13B Proteins) activation.
These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive chronic lymphocytic leukemia.
An important role of TCL1 in activating the ER stress response in support for malignant progression of chronic lymphocytic leukemia.
TCL1 and/or other genes in the TCL1 pathway are responsible for the initiation of human chronic lymphocytic leukemia.
Akt (show AKT1 Proteins) kinase activity can be inhibited by a peptide spanning the betaA strand of the proto-oncogene TCL1
Tcl1 is a coactivator of Akt (show AKT1 Proteins) signaling, in normal T- and B-cell development and function.
Detailed mechanism for TCL1-augmented signaling helps explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes.
Suggest miR (show MLXIP Proteins)-181b as therapeutic target for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model.
High TCL1A expression is associated with chronic lymphocytic leukemia.
Polymorphic genetic variations of cytochrome P450 19A1 (show CYP19A1 Proteins) and T-cell leukemia 1A genes in the Tamil population
Peptide-based TCL1-interphase mimics were potent in steric AKT (show AKT1 Proteins) antagonization.
demonstrated that miR (show MLXIP Proteins)-3676 targets three consecutive 28-bp repeats within 3'UTR of TCL1 and showed that miR (show MLXIP Proteins)-3676 is a powerful inhibitor of TCL1
Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15 (show CDKN2B Proteins);q32) [TCRgamma-TCL1A translocation] confirmed by FISH.
Report frequent TCL1A rearrangements in T-cell prolymphocytic leukemia with cutaneous involvement.
TCL1-Tg:p53(-/-) leukemia cells exhibit higher survival capacity and are more drug resistant than the leukemia cells from TCL1-Tg:p53wt mice
TCL1A and ATM (show ATM Proteins) are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q.
SNPs near the 3' terminus of TCL1A were associated with aromatase (show CYP19A1 Proteins) inhibitors-dependent musculoskeletal pain. Estradiol induced SNP-dependent TCL1A expression.
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998
T-cell leukemia/lymphoma 1A
, T-cell lymphoma-1
, T-cell leukemia/lymphoma protein 1A
, T-cell lymphoma breakpoint 1
, oncogene TCL-1
, oncogene TCL1
, protein p14 TCL1
, T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein)