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T-Cell Leukemia/lymphoma 1A Proteins (TCL1A)

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). Additionally we are shipping T-Cell Leukemia/lymphoma 1A Antibodies (78) and T-Cell Leukemia/lymphoma 1A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCL1A 21432 P56280
TCL1A 8115 P56279
TCL1A 690575  
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Top T-Cell Leukemia/lymphoma 1A Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$772.20
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   10 μg Log in to see 6 Days
$168.54
Details

TCL1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced T-Cell Leukemia/lymphoma 1A Proteins

  1. Human TCL1A Protein expressed in Escherichia coli (E. coli) - ABIN666894 : Herling, Patel, Khalili, Schlette, Kobayashi, Medeiros, Jones: TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. in Leukemia 2006 (PubMed)
    Show all 2 references for ABIN666894

More Proteins for T-Cell Leukemia/lymphoma 1A (TCL1A) Interaction Partners

Mouse (Murine) T-Cell Leukemia/lymphoma 1A (TCL1A) interaction partners

  1. results indicate that decreased Cav-1 (show CAV1 Proteins) in Emu-TCL1 mice significantly delays the onset of CLL and decreases leukemic progression by inhibiting MAPK-Erk (show MAPK1 Proteins) signaling, suggesting a role for Cav-1 (show CAV1 Proteins) in the proliferation and progression of CLL

  2. This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development.

  3. Tcl1 expression downregulated a distinct group of genes, including Ndp52 (show CALCOCO2 Proteins), whose expression is very high in blastocysts but reduced in the primitive ectoderm.

  4. Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI (show TNFRSF13B Proteins) activation.

  5. These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive chronic lymphocytic leukemia.

  6. An important role of TCL1 in activating the ER stress response in support for malignant progression of chronic lymphocytic leukemia.

  7. TCL1 and/or other genes in the TCL1 pathway are responsible for the initiation of human chronic lymphocytic leukemia.

  8. Akt (show AKT1 Proteins) kinase activity can be inhibited by a peptide spanning the betaA strand of the proto-oncogene TCL1

  9. Tcl1 is a coactivator of Akt (show AKT1 Proteins) signaling, in normal T- and B-cell development and function.

  10. Detailed mechanism for TCL1-augmented signaling helps explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes.

Human T-Cell Leukemia/lymphoma 1A (TCL1A) interaction partners

  1. Our results suggest that intratumoral TCL1A+ B cells are important for controlling cervical cancer development.

  2. Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL (show FH Proteins) and call for prospective studies.

  3. We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenstrom macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact.

  4. Suggest miR (show MLXIP Proteins)-181b as therapeutic target for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model.

  5. High TCL1A expression is associated with chronic lymphocytic leukemia.

  6. Polymorphic genetic variations of cytochrome P450 19A1 (show CYP19A1 Proteins) and T-cell leukemia 1A genes in the Tamil population

  7. Peptide-based TCL1-interphase mimics were potent in steric AKT (show AKT1 Proteins) antagonization.

  8. demonstrated that miR (show MLXIP Proteins)-3676 targets three consecutive 28-bp repeats within 3'UTR of TCL1 and showed that miR (show MLXIP Proteins)-3676 is a powerful inhibitor of TCL1

  9. Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15 (show CDKN2B Proteins);q32) [TCRgamma-TCL1A translocation] confirmed by FISH.

  10. Report frequent TCL1A rearrangements in T-cell prolymphocytic leukemia with cutaneous involvement.

T-Cell Leukemia/lymphoma 1A (TCL1A) Protein Profile

Protein Summary

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998

Gene names and symbols associated with TCL1A

  • T-cell leukemia/lymphoma 1A (TCL1A)
  • T cell lymphoma breakpoint 1 (Tcl1)
  • T-cell leukemia/lymphoma 1A (Tcl1a)
  • Tcl1 protein
  • Tcl1a protein

Protein level used designations for TCL1A

T-cell leukemia/lymphoma 1A , T-cell lymphoma-1 , T-cell leukemia/lymphoma protein 1A , T-cell lymphoma breakpoint 1 , TCL-1 , oncogene TCL-1 , oncogene TCL1 , protein p14 TCL1 , T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein)

GENE ID SPECIES
506540 Bos taurus
612421 Canis lupus familiaris
741380 Pan troglodytes
21432 Mus musculus
8115 Homo sapiens
690575 Rattus norvegicus
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