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Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Additionally we are shipping TIAM1 Antibodies (51) and many more products for this protein.
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Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
S1466 of Tiam1 is a novel Cdk1 (show CDK1 Proteins) site whose phosphorylation is required for Tiam1's mitotic function.
endometrial Tiam1/Rac1 signal down-regulation along with miR (show MLXIP Proteins)-22 up-regulation during embryo implantation window in the natural menstrual cycle may be one of the reasons for the failure of embryo implantation in patients with repeated implantation failure
The MAP1B-Tiam1-Rac1 relay is essential for spine structural plasticity and removal of AMPA (show GRIA3 Proteins) receptors from synapses during long-term depression.
Tiam1 is a regulator of the dopaminergic neurons development acting in the Wnt/Dvl/Rac1 pathway.
Tiam1, a specific activator of the small GTPase (show RACGAP1 Proteins) Rac (show AKT1 Proteins), is required for the polarized outgrowth of protrusions in primary astrocytes during the initial phase of cell polarization after scratch-wounding monolayers of cells.
Embryonic Tiam-1 expression plays a critical role during early brain development in mice.
Study shows that the NR2C (show GRIN2C Proteins) and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1 (show ETV1 Proteins).
These findings demonstrate a novel Shh pathway that regulates the actin cytoskeleton via Tiam1-Rac1 activation.
IRSp53 (show BAIAP2 Proteins) and spinophilin (show PPP1R9B Proteins) regulate localized Rac (show AKT1 Proteins) activation by T-lymphocyte invasion and metastasis protein 1
Tiam1 expression significantly increased in cholangiocarcinoma tissues, and increased along with the degree of malignancy of cholangiocarcinoma. Targeted silencing Tiam1 expression could inhibit proliferation and migration activity of cholangiocarcinoma cells.
fibroblast expression patterns of Tiam1 and osteopontin (show SPP1 Proteins) in human breast cancers show converse changes correlating with invasion, supporting the hypothesis that this pathway in tumor-associated fibroblasts regulates breast cancer invasiveness
We identified T lymphoma invasion and metastasis 1 (TIAM1) gene as potential target of miR (show MLXIP Proteins)-329 in gastric cancer
Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling.
The downregulation of MiR (show MLXIP Proteins)-182 is associated with the growth and invasion of osteosarcoma cells through the regulation of TIAM1 expression.
Study identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability and provides new insights on how EGFR signaling triggers Rac1 activation and cancer development.
The polymorphisms rs2833188 and rs2833195 in TIAM1 gene may be associated with some clinical characteristics in children with Kawasaki disease.
These results suggested that Tiam1 overexpression in LSCC is possibly involved in the promotion of migration and invasion, and is a promising therapeutic target in the prevention of the progression of LSCC.
we show that HUWE1 (show HUWE1 Proteins) stimulates human lung cancer cell invasion through regulating TIAM1 stability. Finally, we demonstrate that HUWE1 (show HUWE1 Proteins) and TIAM1 protein levels are inversely correlated in human lung carcinomas
TIAM1 is activated by phosphatidylinositol 5-phosphate which activates RAC1, regulating actin dynamics and cell invasion.
G protein betagamma subunits, Src kinase (show CSK Proteins) and the GEF (show SLC2A4RG Proteins) Tiam1 are upstream modulators of S1P (show MBTPS1 Proteins)-mediated Rac1 activation, and Rac1 has a role in S1P (show MBTPS1 Proteins)-mediated activation of PI 3 (show PI3 Proteins)-kinase/Akt (show AKT1 Proteins)/endothelial nitric-oxide synthase (show NOS3 Proteins) signaling in vascular endothelial cells
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
T-cell lymphoma invasion and metastasis 1
, T-lymphoma invasion and metastasis-inducing protein 1
, T-lymphoma invasion and metastasis-inducing protein 1-like
, t-lymphoma invasion and metastasis-inducing protein 1-like
, human T-lymphoma invasion and metastasis inducing TIAM1 protein