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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Kits (8) and T-Complex Protein 1 Proteins (4) and many more products for this protein.
Showing 10 out of 108 products:
Human Polyclonal TCP1 Primary Antibody for IHC, WB - ABIN2666194
Bénard, Douc-Rasy, Ahomadegbe: TP53 family members and human cancers. in Human mutation 2003
Show all 6 references for ABIN2666194
Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 references for ABIN672336
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions
DeltaNp63alpha is a vital epithelial-mesenchymal transition repressor in cervical squamous cell carcinoma cells. SCC (show CYP11A1 Antibodies) patients with low DeltaNp63alpha expression and high EMT (show ITK Antibodies) level show more frequent metastasis and recurrence as well as reduced overall survival. The miR (show MLXIP Antibodies)-205/ZEB1 (show ZEB1 Antibodies) axis is involved in the inhibition effect of DeltaNp63alpha on EMT (show ITK Antibodies).
Immunocytochemistry using this antibody cocktail comprises five antibodies recognising p63 (show RPE65 Antibodies), and cytokeratins ( 7, 18, 5 and 14) showed good sensitivity and specificity for diagnosing breast cancers. Thus, this method is useful for mammary cytology using FNA
HCC1806 cells endogenously express p63 (show RPE65 Antibodies), mainly as the DeltaNp63alpha isoform. Endogenous p63 (show RPE65 Antibodies) is required to suppress the expression of luminal markers and maintain the basal epithelial phenotype, but p63 (show RPE65 Antibodies) loss is insufficient to induce full luminal-type differentiation. p63 (show RPE65 Antibodies) exerts multiple pro-oncogenic effects on cell differentiation, proliferation and adhesion in basal-like breast cancers.
The findings suggest that miR (show MLXIP Antibodies)-203 is a tumor suppressor that plays an important role in inhibiting the occurrence of Kazakh esophageal squamous cell carcinoma in China via regulating the expression of p63 (show RPE65 Antibodies).
Single-cell pattern is frequently a component of morpheaform basal cell carcinoma. TP63 (show TP63 Antibodies)/cytokeratin (show KRT4 Antibodies) staining may aid in identification of these tumor cells.
Although preliminary, the expression levels of DeltaNp63 mRNA and miR (show MLXIP Antibodies)-203 seem to be promising for cervical cancer screening. In addition, positive correlation between miR (show MLXIP Antibodies)-203 and DeltaNp63 expression suggests the possible existence of some indirect pathways
Study shows that DeltaNp63alpha controls YB-1 (show YBX1 Antibodies) protein stability suggesting that DeltaNp63alpha/YB-1 (show YBX1 Antibodies) cross talk is relevant for survival of basal keratinocytes in stratified epithelia.
results established a cell type-specific function of DeltaNp63alpha in induction of quiescence and downregulation of the BRCA1 pathway which suggested a role of DeltaNp63alpha in the dormancy of luminal breast cancers.
The immunostaining of FNA breast specimens for p63 (show RPE65 Antibodies) and CK 34beta-E12 (show ELSPBP1 Antibodies) may help in difficult diagnoses
p63 (show RPE65 Antibodies) and TCF4 (show TCF4 Antibodies) coexist at a Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) response elements of MMP7 (show MMP7 Antibodies) on the chromatin, where beta-catenin (show CTNNB1 Antibodies) recruitment is attenuated.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa