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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Kits (8) and T-Complex Protein 1 Proteins (4) and many more products for this protein.
Showing 10 out of 106 products:
Human Polyclonal TCP1 Primary Antibody for FACS - ABIN2666196
Ghioni, Bolognese, Duijf, Van Bokhoven, Mantovani, Guerrini: Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. in Molecular and cellular biology 2002
Show all 7 references for ABIN2666196
Human Polyclonal TCP1 Primary Antibody for IHC, WB - ABIN2666194
Bénard, Douc-Rasy, Ahomadegbe: TP53 family members and human cancers. in Human mutation 2003
Show all 6 references for ABIN2666194
Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 references for ABIN672336
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions
Study shows that DeltaNp63alpha controls YB-1 (show YBX1 Antibodies) protein stability suggesting that DeltaNp63alpha/YB-1 (show YBX1 Antibodies) cross talk is relevant for survival of basal keratinocytes in stratified epithelia.
results established a cell type-specific function of DeltaNp63alpha in induction of quiescence and downregulation of the BRCA1 pathway which suggested a role of DeltaNp63alpha in the dormancy of luminal breast cancers.
The immunostaining of FNA breast specimens for p63 (show RPE65 Antibodies) and CK 34beta-E12 (show ELSPBP1 Antibodies) may help in difficult diagnoses
p63 (show RPE65 Antibodies) and TCF4 (show TCF4 Antibodies) coexist at a Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) response elements of MMP7 (show MMP7 Antibodies) on the chromatin, where beta-catenin (show CTNNB1 Antibodies) recruitment is attenuated.
p63 (show RPE65 Antibodies) has both overlapping and distinct functions compared with p53 (show TP53 Antibodies), and that p63 (show RPE65 Antibodies) and mutated p53 (show TP53 Antibodies) antagonize each other
Altogether, these results suggest a novel function for p63 (show RPE65 Antibodies) as a contributor to muscular atrophic processes via the regulation of multiple genes, including the muscle atrophy gene Trim63 (show TRIM63 Antibodies).
results suggest that baicalein-mediated ASK1 (show MAP3K5 Antibodies)/JNK (show MAPK8 Antibodies) activation regulates the mitochondria-dependent apoptosis pathway through the up-regulation of TAp63 and down-regulation of NF-kappaB (show NFKB1 Antibodies) and CD74 (show CD74 Antibodies)/CD44 (show CD44 Antibodies) in B-cell malignancies
Suggest p63 (show RPE65 Antibodies) is a reliable marker in non-small cell lung carcinoma and can be used in differential diagnosis.
demonstrated the role of OTX2 (show OTX2 Antibodies) on TAp63 regulation necessary for the correct formation of macular neuroepithelium
a transcript encoding the death receptor DR5 (show TNFRSF10B Antibodies) originates from an ERV9-LTR inserted upstream of the protein coding regions of the TNFRSF10B (show TNFRSF10B Antibodies) gene, and it shows an expression pattern similar to GTAp63
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa