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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.
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Human Polyclonal TAF1 Primary Antibody for IF, WB - ABIN2452155
Sekiguchi, Nohiro, Nakamura, Hisamoto, Nishimoto: The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. in Molecular and cellular biology 1991
Data show that Taf1 is decreased at the osteogenic initiation stage in the maxilla of Tgfbr2 (show TGFBR2 Antibodies) mutant mice.
TAF1 and TAF1L (show TAF1L Antibodies) genes harbored not only somatic mutations but also mutational ITH.
The bromodomains of BRD9, CECR2 (show CECR2 Antibodies), and the second bromodomain of TAF1 recognize the longer butyryl mark on histones. In addition, the TAF1 second bromodomain is capable of binding crotonyl marks.
TAF1 variants are associated with dysmorphic features, intellectual disability, and neurological manifestations.
TAF1 winged helix domain has intrinsic DNA-binding activity, which depends on characteristic residues that are commonly used by winged helix fold proteins for interacting with DNA.
the surface of the TAF1-TAF7 (show TAF7 Antibodies) complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3 (show HIST3H3 Antibodies)
This study demonistrated that frequencies of polymorphic genotype and allele of TAF1 gene were not different in patients than in control group and that they were not significant for cerebral venous thrombosis.
As cellular ATP levels recover, TAF1 is able to phosphorylate p53 (show TP53 Antibodies) on Thr55, which leads to dissociation of p53 (show TP53 Antibodies) from the p21 (show CDKN1A Antibodies) promoter.
Lower efficiency of microRNA synthesis directed by TATA box or NF-kappaappaB is a consequence of frequent transcription initiations that lead to RNA polymerase II crowding at pause sites and premature termination.
Although d3-d4 also affect genes potentially related to neurodegenerative processes, their physiologic role as splice variants of TAF1 awaits further exploration
analysis of phosphorylation-dependent regulation of cyclin D1 (show CCND1 Antibodies) and cyclin A (show CCNA2 Antibodies) gene transcription by TFIID (show TBP Antibodies) subunits TAF1 and TAF7 (show TAF7 Antibodies)
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.
, TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, neuron specific isoform
, TBP-associated factor 250 kDa
, cell cycle gene 1 protein
, cell cycle, G1 phase defect
, transcription initiation factor TFIID 250 kDa subunit
, transcription initiation factor TFIID subunit 1
, complementation of cell cycle block, G1-to-S
, transcription factor TFIID p250 polypeptide