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Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. Additionally we are shipping TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa Proteins (13) and TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa Kits (2) and many more products for this protein.
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ATF7 (show ATF5 Antibodies) interacts with TAF12 and contributes to the hypersensitivity of OCL (show OCLN Antibodies) precursors to 1,25-(OH)D in PD.
TAF12 and NFYC (show NFYC Antibodies) are transcription factors that regulate the epigenome, whereas RAD54L (show ATRX Antibodies) plays a central role in DNA repair
ATF7 (show AFT7 Antibodies) interacts with TAF12 and contributes to the hypersensitivity of OCL (show OCLN Antibodies) precursors to 1,25-(OH)D in PD.
Data present the crystal structure of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).
histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6 (show TAF6 Antibodies)-TAF9 (show TAF9 Antibodies) and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs
TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription.
Findings suggest that DNA binding by TAF4/4b-TAF12 facilitates the association of TFIID with the core promoter of a subset of genes.
Results suggest that RNA polymerase II carboxy-terminal domain phosphorylation is required for efficient pre-mRNA splicing and 3'-end formation in vivo.
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene.
, TBP-associated factor
, TBP-associated factor 30kD subunit alpha
, TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa
, transcription initiation factor TFIID 20 kDa subunits
, transcription initiation factor TFIID subunit 12
, TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD
, transcription initiation factor TFIID 20/15 kDa subunits
, TFIID subunit p22