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Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP\; see MIM 170260) in the endoplasmic reticulum (ER). Additionally we are shipping TAPBPL Antibodies (58) and many more products for this protein.
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It is now clear there are two MHC class I specific peptide editors, tapasin (show TAPBP Proteins) and TAPBPR, intimately involved in controlling peptide presentation to the immune system.
These results support a role of TAPBPR in stabilizing peptide-receptive conformation(s) of MHC-I, permitting peptide editing.
TAPBPR is a new player in the MHC class I presentation pathway. (Review)
The longer TAPBPR protein interacted with MHC class I but was attenuated in its ability to down-regulate surface expression of MHC class I.
the data indicate that TAPBPR and tapasin bind in a similar orientation to the same face of MHC class I.
The function of the tapasin-related protein, TAPBPR, was investigated.
HLA-I, TAP1 (show TAP1 Proteins), CNX (show CANX Proteins), LMP7 (show PSMB8 Proteins), Erp57 (show PDIA3 Proteins), Tapasin (show TAPBP Proteins) and ERAP1 (show ERAP1 Proteins) were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of esophageal squamous cell carcinoma lesions then, respectively.
Focuses on cloning and characterization of human TAPBP-R but also identifies the mouse ortholog Tapbpl.
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP\; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.
TAP binding protein-like
, TAP binding protein related
, TAP-binding protein-like
, TAP-binding protein-related protein
, tapasin-related protein