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TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. Additionally we are shipping TBC1D1 Antibodies (47) and TBC1D1 Proteins (4) and many more products for this protein.
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the TBC1D1 gene has an effect on meat, carcass and production traits in Italian heavy pigs.
data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT
AS160 and TBC1D1 phosphorylations were evident 30 min after exercise.
Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.
Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain.
R125W mutation occurs in a location of the TBC1D1 PTB (show PTBP1 ELISA Kits) domain that is predicted to have a function in a putative protein:protein interaction.
Data suggest that insulin (show INS ELISA Kits) increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration.
TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.
[review] The question of a mechanism for increased phosphorylation of Se (show APRT ELISA Kits)r237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.
A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Tbc1d1 knockout mice have GLUT4 (show SLC2A4 ELISA Kits) expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 KO/Tbc1d1 KO mice, supporting nonredundant functions for AS160 and Tbc1d1.
Data (including data from mice with Tbc1d1 gene deletion) suggest Tbc1d1 controls basal intracellular GLUT4 (show SLC2A4 ELISA Kits) retention in large skeletal muscles; in small muscles (extensor digitorum longus) Tbc1d1 does not regulate basal GLUT4 (show SLC2A4 ELISA Kits) cell surface exposure.
Findings indicate that the RabGAP TBC1D1 plays a key role in regulating GLUT4 (show SLC2A4 ELISA Kits) protein levels and in exercise-mediated glucose uptake in nonoxidative muscle fibers.
TBC1D1-mediated reduction of muscle fatty acid oxidation appears to occur via inhibition of beta-hydroxyaacyl-CoA dehydrogenase activity.
Data from knockout mice suggest that Tbc1d1 is involved in regulation of energy substrate metabolism (glucose vs. lipids) and energy homeostasis; Tbc1d1 plays important role in susceptibility to diabetes type 2, obesity, and hypertriglyceridemia.
Tbc1d1 serves as a key regulator of aminoimidazole carboxamide ribonucleotide-induced GLUT4 (show SLC2A4 ELISA Kits) liberation
It was shown that TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle. Moreover, functional TBC1D1 was required for AICA ribonucleotide- or contraction-induced metabolic responses.
Leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4.
TBC1D1 Ser237 phosphorylation in skeletal muscle is regulated by alpha2 5AMP-activated protein kinase.
[review] Knockout mice have been used to probe the specific roles of AMP (show TMPRSS5 ELISA Kits) kinase isoforms in contraction-induced Ser237-Tbc1d1 phosphorylation.
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
, TBC1 domain family member 1-like
, TBC1 domain family member 1
, TBC1 domain family, member 1
, tre-2/USP6, BUB2, cdc16) domain family, member 1