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TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 Proteins (TBC1D1)

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. Additionally we are shipping TBC1D1 Antibodies (45) and TBC1D1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TBC1D1 23216 Q86TI0
Rat TBC1D1 TBC1D1 360937  
TBC1D1 57915  
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Top TBC1D1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TBC1D1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) Interaction Partners

Pig (Porcine) TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. the TBC1D1 gene has an effect on meat, carcass and production traits in Italian heavy pigs.

Human TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT

  2. AS160 (show TBC1D4 Proteins) and TBC1D1 phosphorylations were evident 30 min after exercise.

  3. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.

  4. Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain.

  5. R125W mutation occurs in a location of the TBC1D1 PTB (show PTBP1 Proteins) domain that is predicted to have a function in a putative protein:protein interaction.

  6. Data suggest that insulin (show INS Proteins) increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration.

  7. TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.

  8. [review] The question of a mechanism for increased phosphorylation of Se (show APRT Proteins)r237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.

  9. A single bout of exercise regulates TBC1D1 and AS160 (show TBC1D4 Proteins) phosphorylation on multiple sites in human skeletal muscle.

  10. Crystal structures of human TBC1D1 and TBC1D4 (AS160 (show TBC1D4 Proteins)) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 (show SLC2A4 Proteins) translocation.

Mouse (Murine) TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1 (TBC1D1) interaction partners

  1. Tbc1d1 knockout mice have GLUT4 (show SLC2A4 Proteins) expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 (show TBC1D4 Proteins) KO/Tbc1d1 KO mice, supporting nonredundant functions for AS160 (show TBC1D4 Proteins) and Tbc1d1.

  2. Data (including data from mice with Tbc1d1 gene deletion) suggest Tbc1d1 controls basal intracellular GLUT4 (show SLC2A4 Proteins) retention in large skeletal muscles; in small muscles (extensor digitorum longus) Tbc1d1 does not regulate basal GLUT4 (show SLC2A4 Proteins) cell surface exposure.

  3. Findings indicate that the RabGAP TBC1D1 plays a key role in regulating GLUT4 (show SLC2A4 Proteins) protein levels and in exercise-mediated glucose uptake in nonoxidative muscle fibers.

  4. TBC1D1-mediated reduction of muscle fatty acid oxidation appears to occur via inhibition of beta-hydroxyaacyl-CoA dehydrogenase activity.

  5. Data from knockout mice suggest that Tbc1d1 is involved in regulation of energy substrate metabolism (glucose vs. lipids) and energy homeostasis; Tbc1d1 plays important role in susceptibility to diabetes type 2, obesity, and hypertriglyceridemia.

  6. Tbc1d1 serves as a key regulator of aminoimidazole carboxamide ribonucleotide-induced GLUT4 (show SLC2A4 Proteins) liberation

  7. It was shown that TBC1D1 plays a role in regulation of glucose metabolism in skeletal muscle. Moreover, functional TBC1D1 was required for AICA ribonucleotide- or contraction-induced metabolic responses.

  8. Leptin (show LEP Proteins) enhances the intracellular GLUT4 (show SLC2A4 Proteins) transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 (show SLC2A4 Proteins) traffic TBC1D1 and TBC1D4 (show TBC1D4 Proteins).

  9. TBC1D1 Ser237 phosphorylation in skeletal muscle is regulated by alpha2 5AMP-activated protein kinase.

  10. [review] Knockout mice have been used to probe the specific roles of AMP (show TMPRSS5 Proteins) kinase isoforms in contraction-induced Ser237-Tbc1d1 phosphorylation.

TBC1D1 Protein Profile

Protein Summary

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000

Gene names and symbols associated with TBC1D1

  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1)
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (tbc1d1)
  • TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (Tbc1d1)
  • TBC1 domain family, member 1 (Tbc1d1)
  • 1110062G02Rik protein
  • AI385682 protein
  • AW555803 protein
  • mKIAA1108 protein
  • TBC protein
  • Tbc1 protein
  • TBC1D1 protein

Protein level used designations for TBC1D1

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 , TBC1 domain family member 1-like , TBC1 domain family member 1 , lyncein , TBC1 domain family, member 1 , tre-2/USP6, BUB2, cdc16) domain family, member 1

GENE ID SPECIES
461163 Pan troglodytes
479115 Canis lupus familiaris
561193 Danio rerio
697357 Macaca mulatta
100022584 Monodelphis domestica
100055336 Equus caballus
100082442 Ornithorhynchus anatinus
100352741 Oryctolagus cuniculus
100453546 Pongo abelii
100523386 Sus scrofa
100556335 Anolis carolinensis
100601007 Nomascus leucogenys
23216 Homo sapiens
426162 Gallus gallus
282704 Bos taurus
360937 Rattus norvegicus
57915 Mus musculus
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