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Acts as a GTPase activating protein for RAB5. Additionally we are shipping TBC1 Domain Family, Member 3 Antibodies (38) and and many more products for this protein.
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these studies indicate a novel model by which the microtubule network regulates EGFR (show EGFR Proteins) stability and signaling through tubulin (show TUBB Proteins) dimer/oligomer interaction with the nucleocytoplasmic protein TBC1D3.
TBC1D3 is targeted to the plasma membrane by protein palmitoylation.
Growth factor-stimulated TBC1D3 ubiquitination and degradation are regulated by its interaction with CUL7-Fbw8 (show FBXW8 Proteins).
TBC1D3 plays an unanticipated and potentially unique role in the fine-tuning of insulin (show INS Proteins)/IGF-1 (show IGF1 Proteins) signaling
We describe eight highly related TBC1D3 paralogues located on Chromosome 17q12 that display specific transcription patterns in human tissues, and that pattern is altered in several primary prostate tumors in comparison to healthy prostate tissues.
Altered growth factor receptor (show RYK Proteins) trafficking and GTP (show AK3 Proteins)-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans
PRC17 (show TBC1D3B Proteins) is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors.
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
Rab GTPase-activating protein PRC17
, TBC1 domain family member 3
, TBC1 domain family, member 3F
, prostate cancer gene 17 protein
, protein TRE17-alpha
, TBC1 domain family member 3F