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anti-TBC1 Domain Family, Member 4 (TBC1D4) Antibodies

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Additionally we are shipping TBC1D4 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TBC1D4 9882 O60343
TBC1D4 210789 Q8BYJ6
TBC1D4 306117  
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Top anti-TBC1D4 Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TBC1D4 Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane). TBC1D4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of HeLa cells, using AS160 (Ab-642) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TBC1D4 AntibodyTitration: 1.0 µg/mL  Positive Control: 721_B Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using AS160 (Phospho-Thr642) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using AS160 (Phospho-Thr642) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TBC1D4 Antibody (N-term) (ABIN652462) in MDA-MB231 cell line lysates (35 µg/lane). TBC1D4 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human skeletal muscle reacted with TBC1D4 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC212105 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-TBC1D4 antibody (ABIN2454446), and then analyzed by flow cytometry. Anti-TBC1D4 mouse monoclonal antibody (ABIN2454446) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TBC1D4 (RC212105). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details

TBC1D4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TBC1D4 Antibodies

  1. Human Polyclonal TBC1D4 Primary Antibody for EIA, WB - ABIN453848 : Lee, Obata, Yoshida, Stockert, Williamson, Jungbluth, Chen, Old, Scanlan: Immunomic analysis of human sarcoma. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 references for ABIN453848

  2. Human Polyclonal TBC1D4 Primary Antibody for IHC, ELISA - ABIN190878 : Karlsson, Zierath, Kane, Krook, Lienhard, Wallberg-Henriksson: Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. in Diabetes 2005 (PubMed)

  3. Human Polyclonal TBC1D4 Primary Antibody for IF, ELISA - ABIN1532319 : Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: The DNA sequence and analysis of human chromosome 13. ... in Nature 2004 (PubMed)

More Antibodies against TBC1D4 Interaction Partners

Human TBC1 Domain Family, Member 4 (TBC1D4) interaction partners

  1. AS160 and TBC1D1 (show TBC1D1 Antibodies) phosphorylations were evident 30 min after exercise.

  2. homozygous carriers of a nonsense p.Arg684Ter variant have markedly higher concentrations of plasma glucose and serum insulin 2 hours after an oral glucose load compared with individuals with other genotypes

  3. Findings suggest that a dampening of insulin (show INS Antibodies)-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin (show INS Antibodies) resistance evident in a sedentary aging population

  4. insulin (show INS Antibodies) resistance in muscles from healthy individuals is associated with suppression of site-specific phosphorylation of AS160

  5. AS160 interacts with the large cytoplasmic NP domain of the alpha-subunit (show POLG Antibodies) of the Na(+),K(+)-ATPase (show ATP1A1 Antibodies). AMP (show APRT Antibodies)-stimulated protein kinase (show CDK7 Antibodies) (AMPK (show PRKAA1 Antibodies)) and AS160 participate in a common pathway to modulate the cell surface expression of the Na(+),K(+)-ATPase (show ATP1A1 Antibodies).

  6. Crystal structures of human TBC1D1 (show TBC1D1 Antibodies) and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 (show SLC2A4 Antibodies) translocation.

  7. AS160 phosphotyrosine-binding domain constructs inhibit insulin (show INS Antibodies)-stimulated GLUT4 (show SLC2A4 Antibodies) vesicle fusion with the plasma membrane

  8. Impaired insulin (show INS Antibodies)-induced site-specific TBC1D4 phosphorylation may contribute to skeletal muscle insulin (show INS Antibodies) resistance in type 2 diabetes.

  9. results show AS160 phosphorylation level is frequently increased in breast cancer; results implicate a possible role of AS160 in breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target

  10. WNK1 (show WNK1 Antibodies) promotes cell surface expression of glucose transporter GLUT1 (show SLC2A1 Antibodies) by regulating a Tre-2/USP6 (show USP6 Antibodies)-BUB2-Cdc16 (show CDC16 Antibodies) domain family member 4 (TBC1D4)-Rab8A (show RAB8A Antibodies) complex

Mouse (Murine) TBC1 Domain Family, Member 4 (TBC1D4) interaction partners

  1. As160 knockout mice have GLUT4 (show SLC2A4 Antibodies) expression and glucose uptake defects in skeletal muscle and adipose tissue. These defects combine in AS160 KO/Tbc1d1 (show TBC1D1 Antibodies) KO mice, supporting nonredundant functions for AS160 and Tbc1d1 (show TBC1D1 Antibodies).

  2. AS160 has a direct role in linking the trafficking of Na(+),K(+)-ATPase (show ATP1A1 Antibodies) to the energy state of renal epithelial cells

  3. TBC1D4 is dispensable for the regulation of renal Na+ and water transport, but may play a role for GLUT4 (show SLC2A4 Antibodies)-mediated basolateral glucose uptake in distal tubules.

  4. The Thr649 phosphorylation of AS160/TBC1D4 by protein kinase B (show AKT1 Antibodies) plays an important role in the heart electric conduction system through regulating the R-wave amplitude.

  5. AS160 forms a ternary complex with Fsp27 (show CIDEC Antibodies) and Rab8a (show RAB8A Antibodies) to positively regulate lipid droplets fusion.

  6. RAB10 (show RAB10 Antibodies) and its GTPase-activating protein (show RASA1 Antibodies) AS160 comprise the principal signaling module downstream of insulin receptor (show INSR Antibodies) activation that regulates the accumulation of GLUT4 (show SLC2A4 Antibodies) transport vesicles at the plasma membrane.

  7. Data show that the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic clamp study.

  8. Constitutive targeting of AS160 to the plasma membrane increased the surface GLUT4 (show SLC2A4 Antibodies) levels, and this was attributed to both enhanced AS160 phosphorylation and 14-3-3 (show YWHAQ Antibodies) binding and inhibition of AS160 GAP activity.

  9. TBC1D4 may play an important role for the control of renal ion and water handling and hence for the control of extracellular fluid homeostasis.

  10. Because ClipR-59 (show CLIP3 Antibodies) also interacts with Akt (show AKT1 Antibodies) and enhances the interaction between Akt (show AKT1 Antibodies) and AS160, we suggest that ClipR-59 (show CLIP3 Antibodies) functions as a scaffold protein (show HOMER1 Antibodies) to facilitate Akt (show AKT1 Antibodies)-mediated AS160 phosphorylation, thereby regulating glucose transport

TBC1D4 Antigen Profile

Protein Summary

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Gene names and symbols associated with TBC1D4

  • TBC1 domain family, member 4 (TBC1D4) antibody
  • TBC1 domain family, member 4 (Tbc1d4) antibody
  • 5930406J04Rik antibody
  • A930035N22 antibody
  • As160 antibody
  • AV295684 antibody
  • RGD1561609 antibody

Protein level used designations for TBC1D4

Acrg embryonic lethality minimal region ortholog , TBC (Tre-2, BUB2, CDC16) domain-containing protein , TBC1 domain family member 4 , akt substrate of 160 kDa

GENE ID SPECIES
9882 Homo sapiens
210789 Mus musculus
100523015 Sus scrofa
534649 Bos taurus
306117 Rattus norvegicus
Selected quality suppliers for anti-TBC1D4 (TBC1D4) Antibodies
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