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TBC1D7 belongs to a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. Additionally we are shipping TBC1D7 Antibodies (17) and many more products for this protein.
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Each TBC1D7 molecule interacts simultaneously with two parallel TSC1 (show TSC1 Proteins) helices from two TSC1 (show TSC1 Proteins) molecules, suggesting that TBC1D7 may stabilize the TSC (show SLC12A3 Proteins) complex by tethering the C-terminal ends of two TSC1 (show TSC1 Proteins) coiled-coils.
DNA mutational studies allow enlarging the phenotypic spectrum associated with TBC1D7 mutations and defining a TBC1D7 syndrome.
Study suggests that disruption of TBC1D7 causes ID but without the other typical features found in TSC (show SLC12A3 Proteins).
TBC1D7 knockdown results in increased mTORC1 signaling.
Immunohistochemistry of NSCLC tumor tissue suggested an association of TBC1D7 expression with poor prognosis for NSCLC patients; Treatment of lung cancer cells using siRNA against TBC1D7, suppressed its expression and inhibited cell growth.
TBC1D7 belongs to a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6\; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (Nakashima et al., 2007
TBC1 domain family member 7
, cell migration-inducing protein 23