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TBPL1 encodes a member of the TATA box-binding protein family. Additionally we are shipping TBPL1 Proteins (18) and TBPL1 Kits (8) and many more products for this protein.
Showing 10 out of 127 products:
Human Monoclonal TBPL1 Primary Antibody for ChIP, CyTOF - ABIN252470
Stavropoulos, Bradshaw, Li, Pasic, Truong, Ikura, Ungrin, Meyn: The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. in Human molecular genetics 2002
Show all 89 Pubmed References
Chinese Hamster Polyclonal TBPL1 Primary Antibody for ChIP, ICC - ABIN189464
Smith, de Lange: Tankyrase promotes telomere elongation in human cells. in Current biology : CB 2001
Show all 46 Pubmed References
Human Polyclonal TBPL1 Primary Antibody for ChIP, ICC - ABIN252639
Mearini, Chichiarelli, Zampieri, Masciarelli, DErme, Ferraro, Mattia: Interaction of EBV latent origin of replication with the nuclear matrix: identification of S/MAR sequences and protein components. in FEBS letters 2003
Show all 7 Pubmed References
Dog (Canine) Monoclonal TBPL1 Primary Antibody for WB - ABIN968416
Broccoli, Smogorzewska, Chong, de Lange: Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. in Nature genetics 1997
Show all 3 Pubmed References
Human Monoclonal TBPL1 Primary Antibody for IHC, WB - ABIN2668524
Martianov, Fimia, Dierich, Parvinen, Sassone-Corsi, Davidson: Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. in Molecular cell 2001
Show all 2 Pubmed References
Human Polyclonal TBPL1 Primary Antibody for ELISA, WB - ABIN249650
Ohbayashi, Kishimoto, Makino, Shimada, Nakadai, Aoki, Kawata, Niwa, Tamura: Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein. in Biochemical and biophysical research communications 1999
Human Polyclonal TBPL1 Primary Antibody for WB - ABIN1875056
Liu, Liu, Yang, Wang, Li, Zhang: Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells. in Molecular medicine reports 2015
TLP Prevents p53 (show TP53 Antibodies) Degradation through Disrupting the p53 (show TP53 Antibodies)-MDM2 (show MDM2 Antibodies) Interaction.
The interaction of TBP (show TBP Antibodies)-like protein with TFIIA (show GTF2A1 Antibodies) is essential to suppress proteasome-dependent turnover of TBP (show TBP Antibodies)-like protein
miR18a exhibits a protective role in colorectal cancer (CRC (show CALR Antibodies)) via inhibiting proliferation, invasion and migration of CRC (show CALR Antibodies) cells by directly targeting the TBPL1 gene.
results suggest that activation of the p21 (show CDKN1A Antibodies) upstream promoter is mediated by interaction between specific regions of TLP and p53 (show TP53 Antibodies)
Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells.
TLP mediates p53 (show TP53 Antibodies)-governed transcriptional activation of the p21 (show CDKN1A Antibodies) upstream promoter.
Data show that during interphase, endogenous or exogenously expressed TRF2 (show TERF2 Antibodies) is located almost exclusively in the nucleolus
TLF is a functional regulator of transcription with targets distinct from those of TBP (show TBP Antibodies).
the knockdown of the endogenous TLP reduced etoposide-induced apoptosis through repression of TAp63 expression. Taken together, our present study identifies a TLP-TAp63 pathway that is further implicated in stress-induced apoptosis.
Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression.
Transplantation of TRF2 (show TERF2 Antibodies) overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 (show TERF2 Antibodies) transgene was not detectable anymore in the tumors.
transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
TBP-related factor 2 (TRF2) has a role in mouse spermatogenesis
reconfirmed cytoplasmic localization of TRF2 (show TERF2 Antibodies); genotoxins caused it to migrate to the nucleus; TRF2 (show TERF2 Antibodies) may be involved in genotoxin-induced transcriptional regulation
these results demonstrate that TRF2 (show TERF2 Antibodies) increased expression is a potent oncogenic event that along with telomerase deficiency accelerates carcinogenesis, coincidental with a derepression of telomere recombination
Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 (show TERF2 Antibodies) or POT1a (show POT1 Antibodies)/b, and show no evidence of changes or nucleosome eviction near the telomere terminus.
Role of TRF2 (show TERF2 Antibodies) mRNA in male germ cells: In transgenic animals deficient in TRF2 (show TERF2 Antibodies), spermatid development fails during early spermiogenesis with increased apoptosis and failure to develop testicular spermatozoa. Infertility phenotype in homozygote males.
Mice lacking the TBP-related factor 2 (TRF2) gene, which is highly expressed in the testis, have a severe defect in spermiogenesis. TRF2 (show TERF2 Antibodies) expression is shown to be cell type- and stage-specific and play an essential regulatory role in development.
Arabidopsis Pol II is indispensable for endogenous siRNA-mediated transcriptional gene silencing (TGS (show LIN9 Antibodies)) at intergenic low-copy-number loci, despite the presence of two other polymerases-Pol IV and Pol V-that specialize in TGS (show LIN9 Antibodies) through siRNAs
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.
21-kDA TBP-like protein
, TATA box-binding protein-like protein 1
, TATA box-binding protein-related factor 2
, TBP-related factor 2
, TBP-related protein
, second TBP of unique DNA protein
, MIID(1)-5.1 (Probe)
, TATA sequence-binding protein 1
, TATA-binding factor 1
, TATA-binding protein
, TATA-box binding protein
, TATA-box factor 1
, TATA-box-binding protein 1
, TATA-box-binding protein 1(TATA-binding factor 1)(TATA sequence-binding protein 1)
, hypothetical protein
, transcription initiation factor TFIID TBP-1 subunit
, TBP-like factor
, TBP-like protein 1
, TATA box binding protein-like 1
, TATA box-binding protein related factor 2
, TBP-like 1
, tata box-binding protein-like protein 1
, 21 kDa TBP-like protein
, TATA box binding protein-like protein