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TBR1 is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping TBR1 Antibodies (40) and TBR1 Proteins (3) and many more products for this protein.
Our findings highlight a TBR1-regulated network of autism spectrum disorders genes in the developing neocortex that are relatively intolerant to loss-of-function mutations, indicating that these genes may play critical roles in normal cortical development.
T-Brain-1 (TBR1), a causative gene in autism spectrum disorders (ASDs), encodes a brain-specific (show CALY ELISA Kits) T-box transcription factor.
trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2 (show SHANK2 ELISA Kits)-/- and Tbr1+/- mice
Transgenic overexpression of Wnt7b (show WNT7B ELISA Kits) decreased expression of Tbr1 in both progenitor cells and post-mitotic neurons.
This study demonistrated that Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
Results show that the expression of Tbr1 in neural stem and progenitor cells prevents them from following an astrocyte fate during olfactory bulb development.
TBR1 is a direct transcriptional repressor of Fezf2 (show FEZF2 ELISA Kits) and a negative regulator of CS tract formation that restricts the laminar origin of CS axons specifically to L5.
TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 (show FEZF2 ELISA Kits) and CTIP2 (show BCL11B ELISA Kits).
Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons.
Af9/Mllt3 (show MLLT3 ELISA Kits) interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex
TBR1 homodimerizes; it interacts with FOXP2 (show FOXP2 ELISA Kits), a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
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