anti-T-Box 5 (TBX5) Antibodies

TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Additionally we are shipping T-Box 5 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TBX5 6910 Q99593
TBX5 21388 P70326
TBX5 304514 Q5I2P1
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Top anti-T-Box 5 Antibodies at

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-TBX5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, WB TBX5 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TBX5 antibody detected the TBX5 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using TBX5 mouse mAb against HepG2 cell lysate (1) . 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB TBX5 Antibody (N-term) (ABIN658694) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the TBX5 antibody detected the TBX5 protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
Human Mouse Un-conjugated RNAi, ELISA, WB Western blot analysis of TBX5 over-expressed 293 cell line, cotransfected with TBX5 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with TBX5 monoclonal antibody (M01), clone 1G10. GAPDH ( 36.1 kDa ) used as specificity and loading control. Western Blot analysis of TBX5 expression in transfected 293T cell line by TBX5 monoclonal antibody (M01), clone 1G10.Lane 1: TBX5 transfected lysate(57.7 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 11 to 12 Days
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days

TBX5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced anti-T-Box 5 Antibodies

  1. Human Polyclonal TBX5 Primary Antibody for EIA, WB - ABIN955112 : Stirnimann, Ptchelkine, Grimm, Müller: Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. in Journal of molecular biology 2010 (PubMed)
    Show all 5 references for 955112

  2. Cow (Bovine) Polyclonal TBX5 Primary Antibody for IHC, WB - ABIN2777915 : Zaragoza, Lewis, Sun, Wang, Li, Said-Salman, Feucht, Huang: Identification of the TBX5 transactivating domain and the nuclear localization signal. in Gene 2004 (PubMed)
    Show all 3 references for 2777915

  3. Human Monoclonal TBX5 Primary Antibody for RNAi, ELISA - ABIN563098 : Ghosh, Song, Packham, Buxton, Robinson, Ronksley, Self, Bonser, Brook: Physical interaction between TBX5 and MEF2C is required for early heart development. in Molecular and cellular biology 2009 (PubMed)
    Show all 3 references for 563098

  4. Human Polyclonal TBX5 Primary Antibody for IHC (p), WB - ABIN658694 : Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation. in American journal of medical genetics. Part A 2014 (PubMed)

  5. Human Monoclonal TBX5 Primary Antibody for ELISA, WB - ABIN969432 : Collavoli, Hatcher, He, Okin, Deo, Basson: TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. in Journal of molecular and cellular cardiology 2003 (PubMed)

  6. Cow (Bovine) Polyclonal TBX5 Primary Antibody for WB - ABIN2777916 : Riazi, Lee, Hsu, Van Arsdell: CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against T-Box 5 Interaction Partners

Xenopus laevis T-Box 5 (TBX5) interaction partners

  1. we show TBX5 and TBX20 (show TBX20 Antibodies) can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 5 (TBX5) interaction partners

  1. Hence, the variant distribution of NKX2-5 (show NKX2-5 Antibodies), GATA4 (show GATA4 Antibodies) and TBX5 are tightly associated with particular Congenital heart disease subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability

  2. Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4 (show GATA4 Antibodies), cand TBX5)genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage.

  3. Three genes-ATP6V1G1 (show ATP6V1G1 Antibodies) in 9q32, GMPS (show GMPS Antibodies) in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females

  4. report on the association between a TBX5 lossoffunction mutation and increased susceptibility to atrial fibrillation

  5. Whole-genome microarray mRNA-expression profiles of myofibroblasts and skin fibroblasts revealed four additional genes that are significantly differentially expressed in these two cell types: NKX2-3 (show NKX2-3 Antibodies) and LRRC17 (show LRRC17 Antibodies) in myofibroblasts and SHOX2 (show SHOX2 Antibodies) and TBX5 in skin fibroblasts

  6. The Barrett-associated variants at GDF7 (show GDF7 Antibodies) and TBX5 also increase esophageal adenocarcinoma risk.

  7. These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 (show TBX3 Antibodies) and TBX5, and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1 (show LMBR1 Antibodies)

  8. provide both genetic and functional evidence to support the contribution of TBX5 gene in the pathogenesis of Atrial fibrillation

  9. In summary, our study implicated a gene network involving Tbx5, Osr1 (show OXSR1 Antibodies) and Pcsk6 (show PCSK6 Antibodies) interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 in congenital heart disease ontogeny.

  10. The findings expand the mutational spectrum of TBX5 linked to Atrial fibrillation (AF), and provide new evidence that dysfunctional TBX5 may contribute to lone AF.

Mouse (Murine) T-Box 5 (TBX5) interaction partners

  1. The data also suggest that, in human, KLF13 (show KLF13 Antibodies) may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.

  2. Our data demonstrate an early, inherent asymmetry in the left and right limb-forming regions and that threshold levels of Tbx5 are required to overcome this asymmetry to ensure symmetric forelimb formation.

  3. Data show that three transcriptional factors Gata4 (show GATA4 Antibodies), Mef2c (show MEF2C Antibodies), and Tbx5 (abbreviated as GMT (show GAMT Antibodies)) significantly improved murine embryonic stem cells (ESCs (show NR2E3 Antibodies)) differentiated into cardiomyocytes.

  4. defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

  5. Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5 (show NKX2-5 Antibodies), and the zinc finger TF GATA4 (show GATA4 Antibodies) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  6. Tbx5 and Osr1 (show OSR1 Antibodies) interact to regulate posterior second heart field cell cycle progression for cardiac septation.

  7. Haploinsufficiency of Tbx5 and trisomy affects alignment of the aorta and this effect may stem from deviations from normal left-right patterning in the heart; study unveiled a previously unknown interaction between the Tbx5 gene and trisomy, suggesting a connection between Tbx5 and trisomic genes important during heart development.

  8. These findings elucidate mechanisms regulating the commitment of mesodermal cells in the early embryo and identify the Tbx5 cardiac transcriptome.

  9. these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz (show MYST3 Antibodies) germline mutant mice is due to loss of MOZ (show MYST3 Antibodies)-dependant activation of mesodermal Tbx1 (show TBX1 Antibodies) and Tbx5 expression.

  10. our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 (show NKX2-5 Antibodies) and Tbx5 ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 (show NKX2-5 Antibodies) and Tbx5 transcriptional activity.

Zebrafish T-Box 5 (TBX5) interaction partners

  1. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility.

  2. Results show that cul4a (show CUL4A Antibodies) but not cul4b (show CUL4B Antibodies) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

  3. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development.

  4. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis

  5. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos

  6. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20 (show TBX20 Antibodies), and has2 (show HAS2 Antibodies) in the heart

  7. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development.

  8. Pdlim7 (show PDLIM7 Antibodies)/Tbx5 interactions affect the expression of Tbx5 target genes nppa (show NPPA Antibodies) and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects.

  9. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

  10. overexpression of hrT (show TBX20 Antibodies) causes a significant downregulation of tbx5, indicating that one key role of hrT (show TBX20 Antibodies) is to regulate the levels of tbx5

T-Box 5 (TBX5) Antigen Profile

Protein Summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with anti-T-Box 5 (TBX5) Antibodies

  • T-box 5 (TBX5) antibody
  • T-box 5 (tbx5) antibody
  • T-box 5 (LOC100356836) antibody
  • T-box 5 (tbx5-b) antibody
  • T-box 5 (Tbx5) antibody
  • T-box 5a (tbx5a) antibody
  • HOS antibody
  • tbx-5 antibody
  • tbx5 antibody
  • tbx5.1 antibody
  • xtbx-5 antibody
  • xtbx5 antibody
  • zf-tbx5 antibody
  • zTbx5 antibody

Protein level used designations for anti-T-Box 5 (TBX5) Antibodies

T-box 5 , T-box protein 5 , T-box transcription factor 5 , T-box transcription factor TBX5 , T-box transcription factor TBX5-like , t-box transcription factor TBX5-like , T-box gene 5 , T-box gene 5.1 , T-box transcription factor TBX5-A , etID310031.5 , heartstrings , hst , zftbx5a

452276 Pan troglodytes
619589 Xenopus (Silurana) tropicalis
713550 Macaca mulatta
100018880 Monodelphis domestica
100356836 Oryctolagus cuniculus
100397050 Callithrix jacchus
100451005 Pongo abelii
100478001 Ailuropoda melanoleuca
100529166 Oryzias latipes
373738 Xenopus laevis
373988 Gallus gallus
6910 Homo sapiens
491447 Canis lupus familiaris
21388 Mus musculus
304514 Rattus norvegicus
532970 Bos taurus
30071 Danio rerio
Selected quality suppliers for anti-T-Box 5 (TBX5) Antibodies
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