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anti-TC2 (TCN2) Antibodies

TCN2 encodes a member of the vitamin B12-binding protein family.

list all antibodies Gene Name GeneID UniProt
Anti-Human TCN2 TCN2 6948 P20062
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More Antibodies against TC2 Interaction Partners

Human TC2 (TCN2) interaction partners

  1. TCN2 776C --> G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase (show MTHFR Antibodies) 1298AA genotype

  2. Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR (show CD320 Antibodies) 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion

  3. neither MTHFD (show MTHFD1 Antibodies) G1958A nor TC C776G polymorphisms are an independent risk factor for Down syndrome. However, the combined MTHFD (show MTHFD1 Antibodies)/MTHFR (show MTHFR Antibodies), TC/MTHFR (show MTHFR Antibodies) genotypes play a role in the risk of bearing a Down syndrome child in the Chinese population.

  4. Report TCN2 mutations causing transcobalamin deficiency in a family.

  5. Proliferating cancer cells express measurable levels of TCII and TCII-R.

  6. haplotype association analysis revealed a significant association between idiopathic pulmonary fibrosis and transcobalamin II gene polymorphisms

  7. observation suggests that the missense variant Tc2. 776C>G influences both neurotoxicity and efficacy of methotrexate in patients with primary central nervous system lymphoma

  8. preliminary results indicate that transcobalamin 2 gene polymorphisms can be a susceptibility factor for colorectal cancer

  9. Three SNPs in transcobalamin II gene (G1196A, C776G and C1043T) are significantly associated with coronary artery disease in Indian population.

  10. Holotranscobalamin meaesurement does not show superior diagnostic accuracy compared to vitamin B12 (show NDUFB3 Antibodies) for the detection of vitamin B12 (show NDUFB3 Antibodies) deficiency in subjects with neuropsychiatric conditions.

TC2 (TCN2) Antigen Profile

Protein Summary

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-TC2 (TCN2) Antibodies

  • transcobalamin II (TCN2) antibody
  • D22S676 antibody
  • D22S750 antibody
  • II antibody
  • TC antibody
  • TC-2 antibody
  • TC2 antibody
  • TCII antibody
  • TC II antibody

Protein level used designations for anti-TC2 (TCN2) Antibodies

macrocytic anemia , transcobalamin II; macrocytic anemia , transcobalamin-2 , vitamin B12-binding protein 2

6948 Homo sapiens
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