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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Proteins (7) and T-Complex Protein 1 Kits (4) and many more products for this protein.
Showing 10 out of 117 products:
Human Polyclonal TCP1 Primary Antibody for IHC, WB - ABIN2666194
Bénard, Douc-Rasy, Ahomadegbe: TP53 family members and human cancers. in Human mutation 2003
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Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 references for 672336
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
this study shows that CCTalpha (show PCYT1A Antibodies) is required for antigen-specific, germinal center-derived memory B cells
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions
p63 (show RPE65 Antibodies) is a master regulator in epidermal biology and regulates glycolysis sugar taste in the epidermis.
Anaplastic large cell lymphomas without TP63 (show TP63 Antibodies) rearrangements may express TAp63 isoforms of p63 (show RPE65 Antibodies) and this expression is associated with extra copies of TP63 (show TP63 Antibodies), probably due to widespread genomic copy number abnormalities rather than focal gains.
Up-regulation of transcription factor DeltaNp63 led to the decline of miR (show MLXIP Antibodies)-181a expression, resulting in an overexpression of the antiaging protein Sirt1 (show SIRT1 Antibodies), in CD4 (show CD4 Antibodies)(+) T cells from HCV-infected individuals. Either reconstituting miR (show MLXIP Antibodies)-181a or silencing DeltaNp63 or Sirt1 (show SIRT1 Antibodies) expression in CD4 (show CD4 Antibodies)(+) T cells led to accelerated T cell senescence.
Knock-down of WWP1 (show WWP1 Antibodies) abrogates DNA damage-induced down-regulation of DeltaNp63alphaand partially rescues cell apoptosis
The reduction of tumor protein p63 (show TP63 Antibodies) and tumor protein p73 (show TP73 Antibodies) isoforms, rather than alteration of DeltaN isoform expression, exerted a significant functional repercussion on cell death and proliferation in hepatitis B virus -expressing HepB cells.
TGF-beta1 (show TGFB1 Antibodies) increased OSCC cell proliferation by upregulating the expression of DeltaNp63 and c-Myc (show MYC Antibodies) oncogenes. Although the basal OSCC cell proliferation is sustained by activating DeltaNp63, increased induction of c-Myc (show MYC Antibodies) causes unregulated OSCC cell proliferation.
Results suggest that TP63 (show TP63 Antibodies) rs7631358 G > A and CSF1R (show CSF1R Antibodies) rs10079250 A > G may affect the risk and prognosis of lung cancer in never-smoking females.
The findings demonstrate that miR (show MLXIP Antibodies)-203a plays an essential role in keratinocyte proliferation and differentiation caused by extracellular calcium by targeting the SNAI2 (show SNAI2 Antibodies) and DeltaNp63 genes.
Immunohistochemical detection of thyroid transcription factor 1 (show NKX2-1 Antibodies), Napsin A (show NAPSA Antibodies), and P40 (show IL9 Antibodies) fragment of TP63 (show TP63 Antibodies) can be used in the subclassification of non-small cell lung carcinomas.
CK5 (show KRT5 Antibodies) and p40 (show IL9 Antibodies) are good diagnostic markers for squamous cell carcinoma and superior to p63 (show RPE65 Antibodies)
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa