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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Proteins (7) and T-Complex Protein 1 Kits (4) and many more products for this protein.
Showing 10 out of 121 products:
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
Show all 3 Pubmed References
Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 Pubmed References
Human Polyclonal TCP1 Primary Antibody for IF (p) - ABIN909814
Quantius, Schmoldt, Vazquez-Armendariz, Becker, El Agha, Wilhelm, Morty, Vadász, Mayer, Gattenloehner, Fink, Matrosovich, Li, Seeger, Lohmeyer, Bellusci, Herold: Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. in PLoS pathogens 2016
this study shows that CCTalpha (show PCYT1A Antibodies) is required for antigen-specific, germinal center-derived memory B cells
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions
Allele-specific silencing of ectrodactily-ectodermal dysplasia and cleft lip/palate syndrome p63 (show RPE65 Antibodies) mutant R304W restores p63 (show RPE65 Antibodies) transcriptional activity.
Data suggest that this the selective targeting of genes by tumor suppressor protein (show TP53 Antibodies) p63 (p63 (show RPE65 Antibodies)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
This report illustrates the potential severity of urogenital defects in TP63 (show TP63 Antibodies)-related disorders, which may be detectable with fetal ultrasonography. It highlights the need to counsel for the possibility of germline mosaicism in TP63 (show TP63 Antibodies)-associated disorders.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Antibodies) expression via E2F1 transcription factor (show E2F1 Antibodies) 1 (show HNF1A Antibodies), promoting Wasf3/Wave3 (show WASF3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling and bladder cancer invasion
High TP63 (show TP63 Antibodies) expression is associated with growth, metastasis and stemness of oral squamous cell carcinoma.
present observations strongly suggest that RUNX2 (show RUNX2 Antibodies)/mutant p53 (show TP53 Antibodies)/TAp63-regulatory axis is one of the key determinants of SAHA sensitivity of p53 (show TP53 Antibodies)-mutated pancreatic cancer cells
a major effect of p63 (show RPE65 Antibodies) is regulation of cell adhesion, a process important in metastasis and invasion of tumour cells. That this effect is not seen in mesenchymal-type TNBC cells suggests lineage-dependent functions, mirroring the expression of Np63alpha in primary human breast cancers.
p63 (show RPE65 Antibodies) is a master regulator in epidermal biology and regulates glycolysis sugar taste in the epidermis.
Anaplastic large cell lymphomas without TP63 (show TP63 Antibodies) rearrangements may express TAp63 isoforms of p63 (show RPE65 Antibodies) and this expression is associated with extra copies of TP63 (show TP63 Antibodies), probably due to widespread genomic copy number abnormalities rather than focal gains.
Up-regulation of transcription factor DeltaNp63 led to the decline of miR (show MLXIP Antibodies)-181a expression, resulting in an overexpression of the antiaging protein Sirt1 (show SIRT1 Antibodies), in CD4 (show CD4 Antibodies)(+) T cells from HCV-infected individuals. Either reconstituting miR (show MLXIP Antibodies)-181a or silencing DeltaNp63 or Sirt1 (show SIRT1 Antibodies) expression in CD4 (show CD4 Antibodies)(+) T cells led to accelerated T cell senescence.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa