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TCP1 encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. Additionally we are shipping T-Complex Protein 1 Proteins (7) and T-Complex Protein 1 Kits (4) and many more products for this protein.
Showing 10 out of 116 products:
Human Polyclonal TCP1 Primary Antibody for FACS - ABIN2666196
Ghioni, Bolognese, Duijf, Van Bokhoven, Mantovani, Guerrini: Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains. in Molecular and cellular biology 2002
Show all 7 references for ABIN2666196
Human Polyclonal TCP1 Primary Antibody for IF (p), IHC (p) - ABIN672336
Yang, Xie, Shu, Liu, Chen, Ruan, Qi: An improved method for the isolation and culture of rat epidermal stem cells. in International journal of clinical and experimental pathology 2013
Show all 2 references for ABIN672336
Human Polyclonal TCP1 Primary Antibody for ChIP, ICC - ABIN2668832
Rhie, Hazelett, Coetzee, Yan, Noushmehr, Coetzee: Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. in BMC genomics 2014
Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Antibodies) (P2X7R (show P2RX7 Antibodies)) and plays a role in lymphoid neoplasm metastasis.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin (show GSN Antibodies), suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin (show GSN Antibodies) activity, such as cell motility.
Host CCTalpha (show PCYT1A Antibodies) is required for efficient transcription and replication of rabies virus.
Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia
Results suggest that chaperonin containing t-complex protein 1 (CCT) is required for efficient delivery of enzymatically active toxin to the cytosol and are consistent with a direct role for CCT in translocation of LF through the protective antigen pore.
Normal CCT function is ultimately required for the morphogenesis and survival of sensory neurons of the retina.
TRiC (show MARVELD2 Antibodies)-peptide complexes of the heat shock protein 60 (show HSPD1 Antibodies) family are efficient vehicles of cross-presentation in assays in vitro and in mice in vivo; immunization with TRiC (show MARVELD2 Antibodies) purified from a tumor elicits specific protection against a challenge with that tumor.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin
cellular distribution of CCT during spermatogenesis; in the cytoplasm,it associates to the microtubule organizing center and the manchette; in the nucleus, it concentrates at highly condensed chromatin regions
identified a novel genome-wide significant association between SNPs located in an intronic TP63 (show TP63 Antibodies) enhancer and CL/P
ACTL6A (show BAF53A Antibodies) and p63 (show RPE65 Antibodies) collaborate as oncogenic drivers in head and neck squamous cell carcinoma (HNSCC).
p63 (show RPE65 Antibodies) is significantly downregulated in uveal melanoma cell lines. Its expression induces p53 (show TP53 Antibodies)-mediated apoptosis in these cells via transcriptional upregulation of endogenous PERP (show PERP Antibodies). p63 (show RPE65 Antibodies) expression is required for PERP (show PERP Antibodies)-mediated apoptosis in UM.
findings of our study imply that sequential staining of CK20 and E-cadherin prevents false-positive classification of BCC. Furthermore, our study demonstrated that p40 exhibits the same staining pattern in BCC, TE, and TB
polymorphisms in the TP63 and CD40 genes are associated with lung cancer in a Chinese Han population
In diffuse large B-cell lymphoma, PD-1 (show PDCD1 Antibodies) was expressed in tumor-infiltrating lymphocytes of 39.5% patients. PD-L1 (show CD274 Antibodies) was expressed in tumor cells of 26.3% patients, and TP63 (show TP63 Antibodies) was in tumor cells of 31.6% cases. PD-1 (show PDCD1 Antibodies) expression was associated with the patients' gender and B symptoms. PD-1 (show PDCD1 Antibodies) in tumor-infiltrating lymphocytes was related to prolonged overall survival, but PD-L1 (show CD274 Antibodies) expression was associated with worse clinical outcome.
Downregulation of TP63 (show TP63 Antibodies) is associated with colorectal cancer.
These results suggest that whereas GATA-3 and uroplakin II may be most useful in the diagnosis of urothelial carcinoma metastasis, p40 may be additionally suited as a prognostic marker.
TP63 (show TP63 Antibodies) gene mutation is involved in the familial ADULT syndrome diagnosed in a family.
A large number of giant cell tumors of bone (96.8%) are positive for p63 (show RPE65 Antibodies), which is considerably more than any other giant cell-rich lesion.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, T-complex protein 1 subunit alpha
, T-complex protein 1 subunit alpha A
, T-complex protein 1 subunit alpha B
, t-complex polypeptide 1
, tailless complex polypeptide 1A
, tailless complex polypeptide 1B
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, transformation related protein 63
, tumor protein 63 kDa