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Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Additionally we are shipping TEAD2 Proteins (4) and many more products for this protein.
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Human Polyclonal TEAD2 Primary Antibody for WB - ABIN658203
Zhang, Liu, Zha, Zhao, Yao, Zhao, Xiong, Lei, Guan: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. in The Journal of biological chemistry 2009
Show all 2 references for ABIN658203
Cow (Bovine) Polyclonal TEAD2 Primary Antibody for WB - ABIN2780538
Jacquemin, Depetris, Mattei, Martial, Davidson: Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. in Genomics 1999
Cow (Bovine) Polyclonal TEAD2 Primary Antibody for WB - ABIN375139
Sawada, Kiyonari, Ukita, Nishioka, Imuta, Sasaki: Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. in Molecular and cellular biology 2008
TAZ (show TAZ Antibodies) negatively regulate transcription of DeltaNp63 through TEAD1,2,3 and 4 transcription factors.
structural and functional analysis of the YAP (show YAP1 Antibodies)-binding domain of human TEAD2
Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc (show MYC Antibodies) RNA expression, and cells with increased Myc (show MYC Antibodies) expression also became super-competitors.
Tead2 transcription factors are crucial regulators of the cellular distribution of Yap (show YAP1 Antibodies) and Taz (show TAZ Antibodies), and together they control the expression of genes critical for EMT (show ITK Antibodies) and metastasis.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP (show YAP1 Antibodies)/TEAD pathway
These findings provide proof of principle that inhibiting TEAD-YAP (show YAP1 Antibodies) interactions is a pharmacologically viable strategy against the YAP (show YAP1 Antibodies) oncoprotein.
YAP (show YAP1 Antibodies), TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF (show LIF Antibodies).
The transcription factors ETF, E2F1 (show E2F1 Antibodies), and SP-1 (show SP1 Antibodies) seem to play a pronounced role in mediating proliferation-dependent differential gene expression in liver.
Results suggest that DNA methylation (show HELLS Antibodies) is not the primary determinant of Soggy/Tead2 expression.
novel MyoD (show MYOD1 Antibodies)-Tead2-Fgfr4 (show FGFR4 Antibodies) pathway important for effective muscle regeneration
Tead2-deficient mice provide a model for anencephaly.
Tead1 (show TEAD1 Antibodies) and Tead2 are functionally redundant, use YAP (show YAP1 Antibodies) as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in development.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
TEA domain family member 2
, transcriptional enhancer factor TEF-4-like
, transcriptional enhancer factor TEF-4
, embryonic TEA domain-containing factor
, Embryonic TEA domain containing factor