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TELO2 encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. Additionally we are shipping TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) Proteins (3) and many more products for this protein.
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Human Polyclonal TELO2 Primary Antibody for FACS, IHC (p) - ABIN651003
Takai, Wang, Takai, Yang, de Lange: Tel2 regulates the stability of PI3K-related protein kinases. in Cell 2007
Show all 2 references for ABIN651003
IP7, formed by IP6K2 (show IP6K2 Antibodies), binds CK2 (show CSNK2A1 Antibodies) to enhance its phosphorylation of the Tti1 (show TTI1 Antibodies)/Tel2 complex, thereby stabilizing DNA-PKcs (show PRKDC Antibodies) and ATM (show ATM Antibodies). This process stimulates p53 (show TP53 Antibodies) phosphorylation at serine 15 to activate the cell death program.
The CK2 (show CSNK2A1 Antibodies) phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase (show SMG1 Antibodies) functions and is essential for mTOR (show FRAP1 Antibodies) and SMG1 (show SMG1 Antibodies) stability in vivo.
Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.
TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder.
The SAM (show TTN Antibodies) domain of human TEL2 can inhibit the transcriptional activities of ETS1 (show ETS1 Antibodies)/2 and TEL1 (show ATM Antibodies).
Data show that that knockdown of either Tti1 (show TTI1 Antibodies) or Tel2 causes disassembly of mTORC1 and mTORC2 (show CRTC2 Antibodies).
TTI1 (show TTI1 Antibodies) and TTI2 (show TTI2 Antibodies) exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein (show MYLK Antibodies) kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM (show ATM Antibodies)).
This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.
telomere length regulation protein TEL2 homolog
, TEL2, telomere maintenance 2, homolog
, protein clk-2 homolog