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TELO2 encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. Additionally we are shipping TEL2, Telomere Maintenance 2, Homolog (S. Cerevisiae) Antibodies (30) and many more products for this protein.
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IP7, formed by IP6K2 (show IP6K2 Proteins), binds CK2 (show CSNK2A1 Proteins) to enhance its phosphorylation of the Tti1 (show TTI1 Proteins)/Tel2 complex, thereby stabilizing DNA-PKcs (show PRKDC Proteins) and ATM (show ATM Proteins). This process stimulates p53 (show TP53 Proteins) phosphorylation at serine 15 to activate the cell death program.
The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.
Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.
TELO2 missense variants result in loss of function, perturb TTT complex stability, and cause an autosomal-recessive syndromic form of Intellectual Disability Disorder.
The SAM (show TTN Proteins) domain of human TEL2 can inhibit the transcriptional activities of ETS1 (show ETS1 Proteins)/2 and TEL1 (show ATM Proteins).
Data show that that knockdown of either Tti1 (show TTI1 Proteins) or Tel2 causes disassembly of mTORC1 and mTORC2 (show CRTC2 Proteins).
TTI1 (show TTI1 Proteins) and TTI2 (show TTI2 Proteins) exist in multiple complexes, including a 2-MDa complex with TEL2 (telomere maintenance 2), called the Triple T complex, and phosphoinositide-3-kinase-related protein (show MYLK Proteins) kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM (show ATM Proteins)).
This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.
telomere length regulation protein TEL2 homolog
, TEL2, telomere maintenance 2, homolog
, protein clk-2 homolog