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Regulator of the DNA damage response (DDR). Additionally we are shipping and many more products for this protein.
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Human Polyclonal TTI1 Primary Antibody for IP, PLA - ABIN4363421
You, Sobreira, Gable, Jurgens, Grange, Belnap, Siniard, Szelinger, Schrauwen, Richholt, Vallee, Dinulos, Valle, Armanios, Hoover-Fong: A Syndromic Intellectual Disability Disorder Caused by Variants in TELO2, a Gene Encoding a Component of the TTT Complex. in American journal of human genetics 2016
IP7, formed by IP6K2 (show IP6K2 Antibodies), binds CK2 (show CSNK2A1 Antibodies) to enhance its phosphorylation of the Tti1/Tel2 (show TELO2 Antibodies) complex, thereby stabilizing DNA-PKcs (show PRKDC Antibodies) and ATM (show ATM Antibodies). This process stimulates p53 (show TP53 Antibodies) phosphorylation at serine 15 to activate the cell death program.
TTI1 and TTI2 (show TTI2 Antibodies) protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoin
Data show that that knockdown of either Tti1 or Tel2 (show TELO2 Antibodies) causes disassembly of mTORC1 and mTORC2 (show CRTC2 Antibodies).
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
TEL2-interacting protein 1 homolog
, TELO2-interacting protein 1 homolog
, Tel two interacting protein 1
, Tel2 interacting protein 1 homolog
, smg-10 homolog, nonsense mediated mRNA decay factor