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C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1\; MIM 613128) and CTC1 (C17ORF68\; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]..
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reveal a critical role for human Stn1 (show STON1 Proteins) in telomere length maintenance and function, supporting the model that efficient replication of telomeric repeats is critical for long-term viability of normal somatic mammalian cells
The mammalian CST (show GAL3ST1 Proteins) (CTC1-STN1 (show STON1 Proteins)-TEN1) complex is directly involved at several stages of telomere end formation and CST (show GAL3ST1 Proteins) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to complete telomere replication.
data indicate that hTen1 is critical for the telomeric function of hCST (show CMPST Proteins), both in telomere protection and downregulation of telomerase function
TEN1 likely functions in conjunction with CTC1 and STN1 (show STON1 Proteins) at the telomere and elsewhere in the genome.
the human CST (show GAL3ST1 Proteins) (CTC1, STN1 (show STON1 Proteins) and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1 (show POT1 Proteins))-TPP1 (show TPP1 Proteins) telomerase processivity factor
Ctc1-Stn1 (show STON1 Proteins)-Ten1 is a replication protein A (RPA (show RPA1 Proteins))-like complex that is not directly involved in conventional DNA replication at forks but plays a role in DNA metabolism frequently required by telomeres.
C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1\; MIM 613128) and CTC1 (C17ORF68\; MIM 613129) (Miyake et al., 2009
CST complex subunit TEN1
, TEN1 telomerase capping complex subunit homolog
, protein telomeric pathways with STN1 homolog
, telomere length regulation protein TEN1 homolog
, telomeric pathways in association with Stn1, number 1