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The protein encoded by TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. Additionally we are shipping TGIF2 Antibodies (86) and many more products for this protein.
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expression of miR (show MLXIP Proteins)-148a was regulated by DNA methylation (show HELLS Proteins) and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer
miR (show MLXIP Proteins)-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2
Corneal fibroblasts demonstrate the expression of TGIF1 (show TGIF1 Proteins) and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea.
Shows that the homologous mouse Tgif2 gene is necessary (show TGIF1 Proteins) for gastrulation.
Data show that loss-of-function mutations in both Tgif1 (show TGIF1 Proteins) and Tgif2 result in a failure of gastrulation.
TGIF2 has a wide but well controlled expression pattern during mouse development.
The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region.
TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
TGFB-induced factor homeobox 2
, 5'-TG-3' interacting factor 2
, TGF(beta)-induced transcription factor 2
, TGF-beta-induced transcription factor 2
, TGFB-induced factor 2 (TALE family homeobox)
, homeobox protein TGIF2
, transcription growth factor-beta-induced factor 2
, 5'-TG-3'-interacting factor 2
, TALE family homeobox
, TGFB-induced factor 2