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anti-THO Complex 1 (THOC1) Antibodies

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010].. Additionally we are shipping THOC1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
THOC1 9984 Q96FV9
THOC1 225160 Q8R3N6
THOC1 291797  
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Top anti-THOC1 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-THOC1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB THOC1 Antibody (N-term)  western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the THOC1 antibody detected the THOC1 protein (arrow). 0.1 mL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB THOC1 Antibody (C-term) western blot analysis in Y79 cell line lysates (35 µg/lane). This demonstrates the THOC1 antibody detected the THOC1 protein (arrow). Western blot analysis of THOC1 (arrow) using rabbit polyclonal THOC1 Antibody (C-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the THOC1 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated WB THOC1 Antibody (N-term)  western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the THOC1 antibody detected the THOC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IP, IHC (p), WB IP Image Nuclear Matrix Protein p84 antibody [C1C3] immunoprecipitates p84 protein in IP experiments. IP Sample: HepG2 whole cell lysate/extract A : 30 μg whole cell lysate/extract of p84 protein expressing HepG2 cells B : Control with 3 μg of pre-immune rabbit IgG C : Immunoprecipitation of p84 by 3 μg of Nuclear Matrix Protein p84 antibody [C1C3] , 7.5% SDS-PAGE The immunoprecipitated p84 protein was detected by Nuclear Matrix Protein p84 antibody [C1C3] , diluted at 1 : 1000. EasyBlot anti-rabbit IgG (HRP)  was used as a secondary reagent. IHC-P Image Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using Nuclear Matrix Protein p84 , antibody at 1:500 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB THOC1 Antibody (C-term)  western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the THOC1 antibody detected the THOC1 protein (arrow). Western blot analysis of THOC1 (arrow) using rabbit polyclonal THOC1 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the THOC1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated DB 50 μg Log in to see 7 to 9 Days
$285.71
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$463.83
Details

THOC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-THOC1 Antibodies

  1. Human Polyclonal THOC1 Primary Antibody for EIA, WB - ABIN955188 : Yang, Li, Khoury, Alrawi, Goodrich, Tan: Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. in Annals of clinical and laboratory science 2008 (PubMed)
    Show all 2 references for ABIN955188

  2. Cow (Bovine) Polyclonal THOC1 Primary Antibody for IHC, WB - ABIN2778931 : Li, Wang, Zhang, Goodrich: Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. in Molecular and cellular biology 2005 (PubMed)

  3. Human Monoclonal THOC1 Primary Antibody for WB - ABIN659196 : Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: New genetic associations detected in a host response study to hepatitis B vaccine. in Genes and immunity 2010 (PubMed)

More Antibodies against THOC1 Interaction Partners

Human THO Complex 1 (THOC1) interaction partners

  1. Colorectal cancer patients with high levels of Thoc1 expression had poorer overall-survival and disease-free survival, whereas those with lower levels of Thoc1 expression survived longer.

  2. In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.

  3. Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.

  4. This suggests NEDD4-1 (show NEDD4 Antibodies) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (show THOC2 Antibodies) activity.

  5. overexpression of hTREX84 is associated with cancer cell transformation, proliferation and may be regulated by RelA/p65 (show NFkBP65 Antibodies)

  6. We show that human THO (show THOC2 Antibodies) depletion impairs transcription elongation and mRNA export and increases instability associated with DNA breaks, leading to hyper-recombination and gammaH2AX (show H2AFX Antibodies) and 53BP1 (show TP53BP1 Antibodies) foci accumulation

  7. A differential connection between tumorogenesis and the expression levels of human THO (show THOC2 Antibodies) and ALY (show THOC4 Antibodies).

  8. hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors

  9. Thoc1 may be important for neoplastic transformation

  10. Cells respond to AAV infection by activating two DNA damage signaling cascades. The first activates the p84N5 protein, which in turn activates caspase-6 (show CASP6 Antibodies), leading to cell death.

Mouse (Murine) THO Complex 1 (THOC1) interaction partners

  1. granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability

  2. Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth.

  3. Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue.

  4. This suggests NEDD4-1 (show NEDD4 Antibodies) functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO (show THOC2 Antibodies) activity.

  5. results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages

  6. THOC5/Fms interacting protein (show THOC5 Antibodies) is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein (show THOC5 Antibodies) causes the down-regulation of THOC1, which may contribute to altered THO (show THOC2 Antibodies) complex function and cell death

  7. The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described.

  8. These findings support the notion that Thoc1-mediated RNP (show RNPC3 Antibodies) assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo.

THOC1 Antigen Profile

Protein Summary

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).

Gene names and symbols associated with anti-THO Complex 1 (THOC1) Antibodies

  • THO complex 1 (thoc1) antibody
  • THO complex 1 (THOC1) antibody
  • THO complex 1 (Thoc1) antibody
  • THO complex 1 protein (thoc1) antibody
  • 3110002N20Rik antibody
  • AW107452 antibody
  • HPR1 antibody
  • LRRGT00070 antibody
  • MGC114861 antibody
  • NMP-84 antibody
  • P84 antibody
  • P84N5 antibody
  • Tho1 antibody
  • THOC1 antibody

Protein level used designations for anti-THO Complex 1 (THOC1) Antibodies

THO complex subunit 1 , THO complex 1 , nuclear matrix protein p84 , THO complex subunit 1-like , THO complex 1 protein , hTREX84 , tho1

GENE ID SPECIES
373077 Danio rerio
398505 Xenopus laevis
421062 Gallus gallus
455324 Pan troglodytes
697954 Macaca mulatta
100051155 Equus caballus
100123388 Nasonia vitripennis
100393939 Callithrix jacchus
100473279 Ailuropoda melanoleuca
100580031 Nomascus leucogenys
100625217 Sus scrofa
733546 Xenopus (Silurana) tropicalis
9984 Homo sapiens
225160 Mus musculus
291797 Rattus norvegicus
490529 Canis lupus familiaris
100138748 Bos taurus
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