anti-THO Complex 5 (THOC5) Antibodies

Component the THO subcomplex of the TREX complex. Additionally we are shipping THO Complex 5 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
THOC5 8563 Q13769
THOC5 107829 Q8BKT7
THOC5 360972 Q68FX7
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Top anti-THO Complex 5 Antibodies at

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: THOC5 Antibody [NBP1-19160] - FFPE section of human breast carcinoma. Antibody used at a dilution of 1:250. 0.1 mL Log in to see 7 to 9 Days
Frog Rabbit Un-conjugated IHC (p), ELISA Human Spleen (formalin-fixed, paraffin-embedded) stained with THOC5 antibody ABIN214718 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using THOC5 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), ELISA 50 μg Log in to see 12 to 14 Days
Frog Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, IHC 100 μL Log in to see 7 to 9 Days
Bat Rabbit Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ELISA, IHC, WB   100 μL Log in to see 16 Days
Human Rabbit Un-conjugated ICC, IF, WB Western Blot: THOC5 Antibody  - Western blot analysis in human cell line RT-4. Immunocytochemistry/Immunofluorescence: THOC5 Antibody  - Staining of human cell line U-2 OS shows localization to nucleoplasm. 100 μL Log in to see 10 to 13 Days
Frog Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days

THOC5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
, , , , , , , , , , , , , , , , ,
Mouse (Murine) , , ,

Rat (Rattus) , , ,

Top referenced anti-THO Complex 5 Antibodies

  1. Human Polyclonal THOC5 Primary Antibody for IHC (p), IP - ABIN438988 : Ramachandran, Tran, Klebba-Faerber, Kardinal, Whetton, Tamura: An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. in RNA (New York, N.Y.) 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against THO Complex 5 Interaction Partners

Human THO Complex 5 (THOC5) interaction partners

  1. Data suggest that the suppression of the multiple THOC5 target genes may represent a novel strategy for hepatocellular carcinoma (HCC (show FAM126A Antibodies)) therapy.

  2. THOC5 to be a novel gene involved in the regulation of serum HDL (show HSD11B1 Antibodies)-C levels

  3. Authors suggest a model in which human Thoc5 controls polyadenylation site choice through the co-transcriptional loading of CFIm68 (show CPSF6 Antibodies) onto target genes.

  4. show that THOC5 Y225 phosphorylation governs mRNA binding. In addition, CXCL12 (show CXCL12 Antibodies) is shown to induce THOC5 Y225 phosphorylation, and site-directed mutagenesis demonstrates that this modulates motile response

  5. show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation

  6. THOC5 protein expression can potentiate receptor signalling to transcription factor expression and monocyte differentiation.

  7. THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly.

  8. Thoc5 exhibits in vitro RNA-binding activity and is associated with HSP70 (show HSP70 Antibodies) mRNPs in vivo as a component of the stable THO (show THOC2 Antibodies) complex

Mouse (Murine) THO Complex 5 (THOC5) interaction partners

  1. These results imply that murine leukemia virus requires UAP56 (show DDX39B Antibodies), THOC5 and THOC7 (show THOC7 Antibodies), in addition to NXF1 (show NXF1 Antibodies), for nuclear export of viral transcripts.

  2. THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt (show WNT2 Antibodies)) target mRNAs and integrity of the gut (show GUSB Antibodies) epithelial barrier.

  3. Regulation of immediate-early (show JUN Antibodies) gene response by THOC5, a member of mRNA export complex contributes to the M-CSF (show CSF1R Antibodies)-induced macrophage differentiation.

  4. THOC5 may be required for mRNA export under stress and/or upon signaling-induced conditions

  5. THOC5/Fms interacting protein is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein causes the down-regulation of THOC1 (show THOC1 Antibodies), which may contribute to altered THO (show THOC2 Antibodies) complex function and cell death

  6. Wild-type FMIP and FMIPSS5,6AA inhibited M-CSF (show CSF1R Antibodies)-mediated survival signaling, while FMIPSS5,6EE-expressing cells survived and differentiated into macrophages more efficiently than wild-type cells in the presence of M-CSF (show CSF1R Antibodies) or TPA (show PLAT Antibodies)

  7. FMIP influences the differentiation of C/EBP alpha (show CEBPA Antibodies) gene during adipocyte differentiation of multipotent C2C12 cells.

THO Complex 5 (THOC5) Antigen Profile

Protein Summary

Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity).

Gene names and symbols associated with anti-THO Complex 5 (THOC5) Antibodies

  • THO complex 5 (THOC5) antibody
  • THO complex 5 (thoc5) antibody
  • THO complex 5 (Thoc5) antibody
  • 1700060C24Rik antibody
  • A430085L24Rik antibody
  • C22orf19 antibody
  • fc54b09 antibody
  • Fmip antibody
  • fSAP79 antibody
  • PK1.3 antibody
  • Sgk2 antibody
  • THOC5 antibody
  • wu:fc54b09 antibody
  • zgc:56190 antibody
  • zgc:76912 antibody

Protein level used designations for anti-THO Complex 5 (THOC5) Antibodies

THO complex subunit 5 homolog , protein C22orf19 , THO complex 5 , THO complex subunit 5 homolog-like , Fms-interacting protein , NF2/meningioma region protein pK1.3 , PP39.2 , functional spliceosome-associated protein 79 , hTREX90 , placental protein 39.2 , Fms interacting protein , fms-interacting protein , serum/glucocorticoid regulated kinase 2

458742 Pan troglodytes
477534 Canis lupus familiaris
100018184 Monodelphis domestica
100059017 Equus caballus
100173840 Pongo abelii
100412070 Callithrix jacchus
100465138 Ailuropoda melanoleuca
100556468 Anolis carolinensis
8563 Homo sapiens
107829 Mus musculus
360972 Rattus norvegicus
533001 Bos taurus
417019 Gallus gallus
325064 Danio rerio
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