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TIA1 Cytotoxic Granule-Associated RNA Binding Protein Proteins (TIA1)

The product encoded by TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. Additionally we are shipping TIA1 Antibodies (88) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIA1 21841 P52912
TIA1 7072 P31483
TIA1 312510  
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Top TIA1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TIA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) Interaction Partners

Mouse (Murine) TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) interaction partners

  1. This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.

  2. Genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain, similar to the fasting effect.

  3. TIA proteins can function as long-term regulators of the ACTB (show ACTB Proteins) mRNA metabolism in mouse and human cells.

  4. TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.

  5. Either TIA1 or TIAR (show TIAL1 Proteins) inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.

  6. TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo.

  7. Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2 (show PTGS2 Proteins)) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.

  8. TIA-1 and TTP (show ZFP36 Proteins) are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines

  9. TIAR (show TIAL1 Proteins) regulates the relative expression of TIA-1 isoforms.

  10. TIA-1-induced polysome disassembly is required for enhanced mRNA decay

Human TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) interaction partners

  1. AT1R (show AGTR1 Proteins) mRNA is regulated by TIA-1 in a ER stress-dependent manner.

  2. This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.

  3. SERPINE1 (show SERPINE1 Proteins) mRNA dissociates from the translational repressor proteins Ago2 (show EIF2C2 Proteins) and TIA-1 upon platelet activation

  4. Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.

  5. results suggest that TIA-1 and TIAR are two new host factors that interact with 5-UTR of EV71 genome and positively regulate viral replication

  6. TIA1 inhibition of the exon 8 exclusion led to a decrease in SIRT1 (show SIRT1 Proteins)-Exon8 mRNA levels.

  7. TIA proteins can function as long-term regulators of the ACTB (show ACTB Proteins) mRNA metabolism in mouse and human cells.

  8. TIA1-knockdown HeLa cells show an increase in ribosomes and translational machinery components.

  9. Structural insights into the role of binding avidity and the contributions of the TIA-1 RNA recognition motifs for recognition of pyrimidine-rich RNAs.

  10. TIA1 gene expression do not predict prognosis in patients diagnosed with cutaneous T-cell lymphoma.

TIA1 Protein Profile

Protein Summary

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.

Gene names and symbols associated with TIA1

  • nucleolysin TIA-1 isoform p40 (PTRG_10065)
  • nucleolysin TIA-1 isoform p40 (PGTG_08590)
  • nucleolysin tia-1 (AaeL_AAEL006710)
  • nucleolysin tia-1 (CpipJ_CPIJ013665)
  • nucleolysin TIA-1 (VDBG_07004)
  • nucleolysin TIA-1 (MGYG_03339)
  • nucleolysin TIA-1 (Tsp_15456)
  • TIA1 cytotoxic granule-associated RNA binding protein (tia1)
  • cytotoxic granule-associated RNA binding protein 1 (Tia1)
  • TIA1 cytotoxic granule-associated RNA binding protein (TIA1)
  • TIA1 cytotoxic granule-associated RNA binding protein (Tia1)
  • 2310050N03Rik protein
  • AI256674 protein
  • mTIA-1 protein
  • tia-1 protein
  • tia1 protein
  • TIAL1 protein
  • TIAR protein
  • WDM protein

Protein level used designations for TIA1

nucleolysin TIA-1 isoform p40 , nucleolysin tia-1 , nucleolysin TIA-1 , TIA1 cytotoxic granule-associated RNA binding protein , Nucleolysin TIA-1 , RNA-binding protein TIA-1 , T-cell-restricted intracellular antigen-1 , cytotoxic granule-associated RNA-binding protein 1 , p40-TIA-1 (containing p15-TIA-1) , TIA1 cytotoxic granule-associated RNA binding protein-like 1 , nucleolysin TIAR , cytotoxic granule-associated RNA binding protein 1

GENE ID SPECIES
6348364 Pyrenophora tritici-repentis Pt-1C-BFP
10545120 Puccinia graminis f. sp. tritici CRL 75-36-700-3
5568274 Aedes aegypti
6046587 Culex quinquefasciatus
9527427 Verticillium alfalfae VaMs.102
10031129 Arthroderma gypseum CBS 118893
10897100 Trichinella spiralis
100196522 Salmo salar
21841 Mus musculus
7072 Homo sapiens
771327 Gallus gallus
538533 Bos taurus
312510 Rattus norvegicus
610625 Canis lupus familiaris
447385 Xenopus laevis
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