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The product encoded by TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. Additionally we are shipping TIA1 Proteins (5) and many more products for this protein.
Showing 10 out of 119 products:
Human Polyclonal TIA1 Primary Antibody for ELISA, IHC (p) - ABIN253097
Yang, Peng, Murray, Otsuka, Kedersha, Schoenberg: Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1. in Molecular and cellular biology 2006
TIA1 knockdown or knockout inhibits tau misfolding and associated toxicity in cultured hippocampal neurons, while overexpressing TIA1 induces tau misfolding and stimulates neurodegeneration.
This study showed that reactive oxygen species such as H2O2 oxidize the cytoplasmic stress granules (SG)-nucleating protein TIA1, thereby inhibiting SG assembly.
Genetic ablation of the stress granule nucleator TIA-1 has a novel major effect on mRNAs encoding lipid homeostasis factors in the brain, similar to the fasting effect.
TIA proteins can function as long-term regulators of the ACTB (show ACTB Antibodies) mRNA metabolism in mouse and human cells.
TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.
Either TIA1 or TIAR (show TIAL1 Antibodies) inactivation broadly alter normal development-associated signalling pathways in murine embryonic fibroblasts.
TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo.
Data suggest that TIA-1 functions as a translational silencer of cyclooxygenase-2 (COX-2 (show PTGS2 Antibodies)) expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 (show COX2 Antibodies) expression in neoplasia.
TIA-1 and TTP (show ZFP36 Antibodies) are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines
TIAR (show TIAL1 Antibodies) regulates the relative expression of TIA-1 isoforms.
studied a novel Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS (show IGFALS Antibodies)/FTD (show FTL Antibodies)) family and identified the P362L mutation in the low-complexity domain (LCD) of TIA1; genetic association analyses showed an increased burden of TIA1 LCD mutations in ALS (show IGFALS Antibodies) patients compared to controls; TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition
Here we designed UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 (show RRM2 Antibodies) and RRM3 and demonstrated that the TIA-1 RRM23 construct preferentially binds the UC-rich RNA ligand. Together our data support a specific mode of TIA-1 RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 in binding RNA to regulate gene expression
miR (show MLXIP Antibodies)-19a could promote cell proliferation and migration in CRC (show CALR Antibodies) cells and accelerated tumor growth in xenograft mice by targeting TIA1.
Data suggest that TPD52 (tumor protein D52) and a TPD52 fragment (residues 78-280) along with TIA-1 (T-cell intracellular antigen-1) and TIAR (TIA-1-related protein (show TIAL1 Antibodies)) contribute to mRNA stability as cis (show CISH Antibodies)-acting and trans-acting factors; 3prime-untranslated regions of TPD52, TPD53, and TPD54 regulate expression of their respective genes in a post-transcriptional manner by altering mRNA stability.
The results provide a mechanism for exon 16 3' splice site activation in which a coordinated effort among TIA1, Pcbp1 (show PCBP1 Antibodies), and RBM39 (show RBM39 Antibodies) stabilizes or increases U2 snRNP (show LSM2 Antibodies) recruitment, enhances spliceosome A complex formation, and facilitates exon definition through RBM39 (show RBM39 Antibodies)-mediated splicing regulation.
AT1R (show AGTR1 Antibodies) mRNA is regulated by TIA-1 in a ER stress-dependent manner.
SERPINE1 (show SERPINE1 Antibodies) mRNA dissociates from the translational repressor proteins Ago2 (show EIF2C2 Antibodies) and TIA-1 upon platelet activation
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
results suggest that TIA-1 and TIAR (show TIAL1 Antibodies) are two new host factors that interact with 5-UTR (show UTS2R Antibodies) of EV71 genome and positively regulate viral replication
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
nucleolysin TIA-1 isoform p40
, nucleolysin tia-1
, nucleolysin TIA-1
, TIA1 cytotoxic granule-associated RNA binding protein
, Nucleolysin TIA-1
, RNA-binding protein TIA-1
, T-cell-restricted intracellular antigen-1
, cytotoxic granule-associated RNA-binding protein 1
, p40-TIA-1 (containing p15-TIA-1)
, TIA1 cytotoxic granule-associated RNA binding protein-like 1
, nucleolysin TIAR
, cytotoxic granule-associated RNA binding protein 1