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Required for normal progression of S-phase. Additionally we are shipping TIPIN Antibodies (65) and TIPIN Kits (12) and many more products for this protein.
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Mta2 (show MTA2 Proteins) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.
data indicate that Tipin/Tim1/And1 (show WDHD1 Proteins) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion
TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.
Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (show MERTK Proteins) DNA ligand.
Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.
We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.
RPA (show RPA1 Proteins)-covered ssDNA not only supports recruitment and activation of ATR (show ANTXR1 Proteins) but also, through Tipin and Claspin, it plays an important role in the action of ATR (show ANTXR1 Proteins) on its critical downstream target Chk1 (show CHEK1 Proteins)
The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.
Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint
observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells
TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.
These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA.
mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes
The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 (show CHEK1 Proteins) pathway for continued DNA synthesis.
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).
timeless interacting protein
, TIMELESS interacting protein
, timeless-interacting protein
, TIMELESS-interacting protein
, CSM3 homolog
, mitotic phosphoprotein 67