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TIMELESS Interacting Protein Proteins (TIPIN)

Required for normal progression of S-phase. Additionally we are shipping TIPIN Antibodies (65) and TIPIN Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIPIN 100359731  
TIPIN 54962 Q9BVW5
TIPIN 66131 Q91WA1
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Top TIPIN Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,722.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,744.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,982.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

TIPIN Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,
Mouse (Murine)

More Proteins for TIMELESS Interacting Protein (TIPIN) Interaction Partners

Xenopus laevis TIMELESS Interacting Protein (TIPIN) interaction partners

  1. Mta2 (show MTA2 Proteins) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.

  2. data indicate that Tipin/Tim1/And1 (show WDHD1 Proteins) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion

Human TIMELESS Interacting Protein (TIPIN) interaction partners

  1. TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.

  2. Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (show MERTK Proteins) DNA ligand.

  3. Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.

  4. We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.

  5. RPA (show RPA1 Proteins)-covered ssDNA not only supports recruitment and activation of ATR (show ANTXR1 Proteins) but also, through Tipin and Claspin, it plays an important role in the action of ATR (show ANTXR1 Proteins) on its critical downstream target Chk1 (show CHEK1 Proteins)

  6. The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.

  7. Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint

  8. observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells

  9. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  10. These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA.

Mouse (Murine) TIMELESS Interacting Protein (TIPIN) interaction partners

  1. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes

  2. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.

  3. The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 (show CHEK1 Proteins) pathway for continued DNA synthesis.

TIPIN Protein Profile

Protein Summary

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

Gene names and symbols associated with TIPIN

  • timeless interacting protein (tipin)
  • TIMELESS interacting protein (TIPIN)
  • timeless interacting protein (LOC100359731)
  • timeless interacting protein (Tipin)
  • XTimeless interacting protein (xtipin)
  • 1110005A05Rik protein
  • 1110018P21Rik protein
  • MGC82649 protein
  • RGD1564084 protein
  • tipin protein
  • zgc:91928 protein

Protein level used designations for TIPIN

timeless interacting protein , TIMELESS interacting protein , timeless-interacting protein , TIMELESS-interacting protein , CSM3 homolog , mitotic phosphoprotein 67

GENE ID SPECIES
444047 Xenopus laevis
453525 Pan troglodytes
100126681 Xenopus (Silurana) tropicalis
100359731 Rattus norvegicus
445058 Danio rerio
415548 Gallus gallus
54962 Homo sapiens
100683743 Canis lupus familiaris
506176 Bos taurus
66131 Mus musculus
363076 Rattus norvegicus
394376 Xenopus laevis
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