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Required for normal progression of S-phase. Additionally we are shipping TIPIN Proteins (10) and TIPIN Kits (5) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal TIPIN Primary Antibody for WB - ABIN1881887
Kemp, Akan, Yilmaz, Grillo, Smith-Roe, Kang, Cordeiro-Stone, Kaufmann, Abraham, Sancar, Unsal-Kaçmaz: Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Human Polyclonal TIPIN Primary Antibody for ICC, IF - ABIN4359856
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Show all 2 Pubmed References
Mta2 (show MTA2 Antibodies) and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate.
data indicate that Tipin/Tim1 (show TIMELESS Antibodies)/And1 (show WDHD1 Antibodies) form a complex that links stabilization of replication fork and establishment of sister chromatid cohesion
the 1.85 A crystal structure of a large N-terminal segment of human Timeless (show TIMELESS Antibodies), spanning amino acids 1-463, is presented and this region of human Timeless (show TIMELESS Antibodies) harbours a partial binding site for Tipin.
TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer.
Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer (show MERTK Antibodies) DNA ligand.
Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins.
We now show that cellular DNA replication fork pausing and protection factors Timeless (show TIMELESS Antibodies) (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle.
RPA (show RPA1 Antibodies)-covered ssDNA not only supports recruitment and activation of ATR (show ANTXR1 Antibodies) but also, through Tipin and Claspin (show CLSPN Antibodies), it plays an important role in the action of ATR (show ANTXR1 Antibodies) on its critical downstream target Chk1 (show CHEK1 Antibodies)
The results suggest that Timeless (show TIMELESS Antibodies)-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks.
Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin (show CLSPN Antibodies) in response to replication checkpoint
observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless (show TIMELESS Antibodies)-depleted cells
TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.
mTIM (show TIMELESS Antibodies) promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM (show TIMELESS Antibodies) activity by disrupting the ability of mTIM (show TIMELESS Antibodies) to form homo-multimeric complexes
The tim-Tipin dysfunction creates an indispensible reliance on the ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies) pathway for continued DNA synthesis.
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be required in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).
timeless interacting protein
, TIMELESS interacting protein
, timeless-interacting protein
, TIMELESS-interacting protein
, CSM3 homolog
, mitotic phosphoprotein 67