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anti-TIMP Metallopeptidase Inhibitor 2 (TIMP2) Antibodies

TIMP2 is a member of the TIMP gene family.

list all antibodies Gene Name GeneID UniProt
Anti-Human TIMP2 TIMP2 7077 P16035
Anti-Rat TIMP2 TIMP2 29543 P30121
Anti-Mouse TIMP2 TIMP2 21858  
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More Antibodies against TIMP Metallopeptidase Inhibitor 2 Interaction Partners

Human TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. our results revealed miR (show MLXIP Antibodies)-483-5p directly targeted to the cartilage matrix protein (show MATN1 Antibodies) matrilin 3 (Matn3 (show MATN3 Antibodies)) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA.

  2. Stromal TIMP-2 expression reflected its role in regulating tumor progression in ameloblastoma and in regulating developmental processes in tooth germs by their inhibitory effect on MMP-9 (show MMP9 Antibodies)

  3. No significant differences were found between MMP-7 (show MMP7 Antibodies) A-181G, C-115T, and TIMP-2 G-418C polymorphism and coronary artery disease and myocardial infarction in a Turkish population.

  4. High TIMP2 expression is associated with chronic myelogenous leukemia.

  5. No significant association was observed in MMP13 (show MMP13 Antibodies), TIMP2 and TGFB3 (show TGFB3 Antibodies) genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13 (show MMP13 Antibodies), TIMP2 and TGFB3 (show TGFB3 Antibodies) genes

  6. MMP-2 (show MMP2 Antibodies) and TIMP-2 were secreted by both tumor cells and stromal cells.

  7. miR (show MLXIP Antibodies)-22 significantly upregulated the invasion capacity of 1321N1 cells. In silico analysis predicted that TIMP2 is a target gene of miR (show MLXIP Antibodies)-22 which was confirmed by qPCR and Western blotting. Luciferase reporter assays demonstrated that miR (show MLXIP Antibodies)-22 directly bound the 3'-untranslated regions of TIMP2. These data suggest that miR (show MLXIP Antibodies)-22 acts to regulate invasion of 1321N1 astrocytoma cells by targeting TIMP2 expression.

  8. TIMP-1 (show TIMP1 Antibodies) and-2 are primarily markers of an early function of the transplanted kidney.

  9. Results show decreased expression of MMP-2 (show MMP2 Antibodies), MMP-9 (show MMP9 Antibodies) and TIMP-2 genes on both mRNA and protein levels in depression; there elevated expression positively affects cognitive efficiency.

  10. TIMP- 2 expression decreased in cervical disc herniation patients.

Cow (Bovine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. Data indicate the involvement of PKC-alpha (show PKCa Antibodies) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.

  2. A differential pattern of matrix metalloproteinase-2 (show MMP2 Antibodies) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  3. MMP-14 (show MMP14 Antibodies), MMP-2 (show MMP2 Antibodies) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  4. Results describe distinct changes in expression of MMP2 (show MMP2 Antibodies), MMP14 (show MMP14 Antibodies), and the metallopeptidase (show ECEL1 Antibodies) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

  5. Production of TIMP-1 (show TIMP1 Antibodies) was augmented by IL-1alpha, TNFalpha (show TNF Antibodies), and hepatocyte growth factor (show HGF Antibodies) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  6. the different temporal expression patterns of TIMP-1 (show TIMP1 Antibodies) and TIMP-2 suggest that TIMP-1 (show TIMP1 Antibodies) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle

  8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (show MMP2 Antibodies)) from the MMP-2 (show MMP2 Antibodies)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (show MMP2 Antibodies) and the complex itself.

  9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (show MMP2 Antibodies) subsequently inhibits Na+ dependent Ca2 (show CA2 Antibodies)+ uptake in the microsomes

  10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

Mouse (Murine) TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (show TIMP1 Antibodies) during the pathogenesis of atherosclerosis

  2. Further investigation of MMP2 (show MMP2 Antibodies) inhibitors of TIMP2/TIMP4 (show TIMP4 Antibodies) showed an upregulated TIMP2 expression, but not TIMP4 (show TIMP4 Antibodies). low-dose pre-radiation attenuates the skin inflammation and ROS (show ROS1 Antibodies) production induced by medium-dose UV radiation

  3. TIMP2 and TIMP3 (show TIMP3 Antibodies) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  4. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (show MAPK14 Antibodies) signaling pathway.

  5. High TIMP2 expression is associated with liver fibrosis.

  6. TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (show MMP2 Antibodies) activation

  7. Gene expression of Mmp-12 (show MMP12 Antibodies) and Mmp-13 (show MMP13 Antibodies), and Timp-1 (show TIMP1 Antibodies) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (show MMP2 Antibodies), and Mmp-9 (show MMP9 Antibodies) expression was modest.

  8. Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (show TGFB1 Antibodies), PAI-1 (show SERPINE1 Antibodies) and RAGE (show AGER Antibodies) in diabetic db/db (show LEPR Antibodies) cells.

  9. This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.

  10. In neural stem cells, TIMP-2 acts as key effector of the proneurogenic response to inducing stimuli such as Marimastat.

Xenopus laevis TIMP Metallopeptidase Inhibitor 2 (TIMP2) interaction partners

  1. overexpression of TIMP-2 N- and C-terminal domains results in severe developmental defects and death, as well as unique changes in MMP-2 (show MMP2 Antibodies) and -9 expression, indicating that the individual domains may regulate MMPs through distinct mechanisms

  2. characterization of Xenopus tissue inhibitor of metalloproteinases-2

TIMP Metallopeptidase Inhibitor 2 (TIMP2) Antigen Profile

Protein Summary

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Gene names and symbols associated with TIMP2

  • TIMP metallopeptidase inhibitor 2 (TIMP2) antibody
  • TIMP metallopeptidase inhibitor 2 (Timp2) antibody
  • tissue inhibitor of metalloproteinase 2 (Timp2) antibody
  • TIMP metallopeptidase inhibitor 2 (timp2) antibody
  • tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) antibody
  • Metalloproteinase inhibitor 2 (timp2) antibody
  • CSC-21K antibody
  • D11Bwg1104e antibody
  • DDC8 antibody
  • MGC84288 antibody
  • MGC108274 antibody
  • TIMP-2 antibody
  • timp2 antibody

Protein level used designations for TIMP2

TIMP-2 , metalloproteinase inhibitor 2 , tissue inhibitor of metalloproteinase 2 , tissue inhibitor of metalloproteinases 2 , tissue inhibitor of matrix metalloproteinase-2 , tissue inhibitor of metalloproteinase-2 , collagenase inhibitor , tissue inhibitor of mettaloproteinase 2 , TIMP metallopeptidase inhibitor 2 , Metalloproteinase inhibitor 2

7077 Homo sapiens
29543 Rattus norvegicus
374178 Gallus gallus
403633 Canis lupus familiaris
282093 Bos taurus
21858 Mus musculus
447572 Xenopus laevis
548477 Xenopus (Silurana) tropicalis
574357 Macaca mulatta
100196250 Salmo salar
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