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anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) Antibodies

TIMP3 belongs to the TIMP gene family. Additionally we are shipping TIMP3 Kits (81) and TIMP3 Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TIMP3 7078 P35625
TIMP3 25358  
TIMP3 21859 P39876
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Top anti-TIMP3 Antibodies at antibodies-online.com

Showing 10 out of 174 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB TIMP3 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using TIMP3 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB The TIMP-3 Antibody is used in Western blot to detect TIMP-3 in rat liver lysates. TIMP-3 staining in human stomach cancer. Paraffin-embedded human stomach cancer is stained with TIMP-3 Antibody used at 1:200 dilution. 0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Mouse PE FACS Detection of TIMP-3 in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human TIMP-3 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 6 to 7 Days
$400.31
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-TIMP-3 Polyclonal Antibody (ABIN668361), Unconjugated at 1:100, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-TIMP-3 Polyclonal Antibody , Unconjugated at 1:100, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-TIMP3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: MCF7 cell lysate WB Suggested Anti-TIMP3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 21 to 31 Days
$164.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of rat kidney tissue lysis using TIMP3 antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TIMP3 Antibody (Center) (ABIN653069) in HepG2 cell line lysates (35 µg/lane). TIMP3 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details

TIMP3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TIMP3 Antibodies

  1. Human Polyclonal TIMP3 Primary Antibody for IF (p), IHC (p) - ABIN668361 : Liu, Cui, Ao, Zhou, Zhou, Yuan, Xiang, Liu, Cao et al.: Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of ... in Toxicology and applied pharmacology 2011 (PubMed)
    Show all 5 references for ABIN668361

  2. Human Polyclonal TIMP3 Primary Antibody for EIA, FACS - ABIN955222 : Wick, Härönen, Mumberg, Bürger, Olsen, Budarf, Apte, Müller: Structure of the human TIMP-3 gene and its cell cycle-regulated promoter. in The Biochemical journal 1995 (PubMed)
    Show all 2 references for ABIN955222

  3. Human Polyclonal TIMP3 Primary Antibody for ELISA, WB - ABIN1533421 : Silbiger, Jacobsen, Cupples, Koski: Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family. in Gene 1994 (PubMed)

  4. Human Monoclonal TIMP3 Primary Antibody for FACS - ABIN4896675 : Mahller, Vaikunth, Ripberger, Baird, Saeki, Cancelas, Crombleholme, Cripe: Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. in Cancer research 2008 (PubMed)

  5. Human Polyclonal TIMP3 Primary Antibody for IHC, ELISA - ABIN1585860 : Nakasone, Terasako-Saito, Yamazaki, Sato, Tanaka, Sakamoto, Kurita, Yamasaki, Wada, Ishihara, Kawamura, Machishima, Ashizawa, Kimura, Kikuchi, Tanihara, Kanda, Kako, Nishida, Yamada, Kanda: Impact of high-/middle-molecular-weight adiponectin on the synthesis and regulation of extracellular matrix in dermal fibroblasts. in Experimental hematology 2014 (PubMed)

More Antibodies against TIMP3 Interaction Partners

Human TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. TIMP-3 expression is suppressed by promoter methylation in HCC (show FAM126A Antibodies).

  2. Both TIMP3 and APC (show APC Antibodies) methylation were associated with lymph node metastasis and higher clinical stage of tumors. Patients with methylation at TIMP3 or APC (show APC Antibodies) had worse prognoses as compared to those without these alterations.

  3. Data indicate the TGF-beta (show TGFB1 Antibodies) pathway regulates the epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 via the Smad2 (show SMAD2 Antibodies)/3/4-dependent pathway.

  4. Study identifies 2 urinary biomarkers-bFGF (show FGF2 Antibodies) and TIMP3-that successfully detect one of the most common pediatric brain tumors, juvenile pilocytic astrocytomas, with high accuracy

  5. the levels of TIMP-3, and in some cases also TIMP-2 (show TIMP2 Antibodies), are decreased in Emery-Dreifuss muscular dystrophy (EDMD (show EMD Antibodies)). The decrease might be associated with an adverse effect on matrix metalloproteinases and remodelling of the myocardial matrix. The specific decrease of TIMP-3 indicates that this biomarker might help in early detection of cardiac involvement in EDMD (show EMD Antibodies).

  6. TIMP3 knockdown had opposite effects on the regulation of these genes.

  7. significant differences were detected concerning the activity of TIMPs resulting in a negative correlation of TIMP1 (show TIMP1 Antibodies) activity with MMP2 (show MMP2 Antibodies) activity (p = 0.044) and negative correlations of TIMP2 (show TIMP2 Antibodies) and TIMP3 with MMP9 (show MMP9 Antibodies) activity

  8. This case series suggests the C113G TIMP3 variant may represent a novel highly penetrant mutation causing choroidal neovascularisation of relatively late onset for Sorsby's fundus dystrophy, mimicking early onset AMD (show AMD1 Antibodies).

  9. expression of TIMP3 is low in pituitary adenomas including ACTH (show POMC Antibodies)-secreting pituitary adenomas and negatively associated with tumor aggressiveness.

  10. Genotypes of rs135025 and rs80272 in TIMP3 contribute to the development of preeclampsia in Han Chinese women.

Rabbit TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 (show MMP1 Antibodies) and decreased TIMP-3 secretion.

  2. TIMP-3 is downregulated in a distinct subpopulation of atherosclerotic foam cells which have increased MMP-14 (show MMP14 Antibodies).

Cow (Bovine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. Reactive oxygen species mediate TGF-beta1 (show TGFB1 Antibodies)-induced TIMP-3 gene expression

  2. TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

  3. TIMP3 mRNA expression level was upregulated by multidirectional articular motion.

Xenopus laevis TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.

  2. metamorphic tail and intestine RNA levels of TIMP-2 (show TIMP2 Antibodies), MT1-MMP (show MMP14 Antibodies) and Gel-A, but not MT3-MMP (show MMP24 Antibodies) or TIMP-3, are elevated during periods of cell death and proliferation

Mouse (Murine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI, an area with few if any therapeutic options.

  2. Elevated levels of TIMP3 and vitronectin (show VTN Antibodies), acting downstream of Notch3 (show NOTCH3 Antibodies)(ECD (show ECD Antibodies)) deposition, play a role in CADASIL (show NOTCH3 Antibodies), producing divergent influences on early CBF (show CEBPZ Antibodies) deficits and later white matter lesions.

  3. 4-Hydroxyisoleucine improved insulin (show INS Antibodies) resistant-like state in 3T3-L1 adipocytes by targeting TACE (show ADAM17 Antibodies)/TIMP3 and the insulin (show INS Antibodies) signaling pathway.

  4. In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten (show PTEN Antibodies)(-/-), Timp3(-/-) prostate tumors compared to Pten (show PTEN Antibodies)(-/-), Timp3(+/+) tumors.

  5. Timp3 status determines p53 (show TP53 Antibodies), p38 (show CRK Antibodies) and Notch (show NOTCH1 Antibodies) coactivation to instruct hepatic cell fate and transformation.

  6. TIMP2 (show TIMP2 Antibodies) and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  7. Expansion of stem cells counteracts age-related mammary regression in compound Timp1 (show TIMP1 Antibodies)/Timp3-deficient mice.

  8. lack of TIMP3 increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis.

  9. TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT mice, possibly due to increased mitochondrial activity.

  10. TIMP3 protects kidney from damage

Pig (Porcine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) interaction partners

  1. These results suggest the crucial role of TIMP-3 in successful implantation and embryo survival and indicate the endometrial stromal decidualization-like in pigs.

TIMP3 Antigen Profile

Protein Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

Gene names and symbols associated with TIMP3

  • metalloproteinase inhibitor 3 (CpipJ_CPIJ003282) antibody
  • TIMP metallopeptidase inhibitor 3 (TIMP3) antibody
  • Metalloproteinase inhibitor 3 (timp3) antibody
  • TIMP metallopeptidase inhibitor 3 (Timp3) antibody
  • TIMP metallopeptidase inhibitor 3 (timp3) antibody
  • tissue inhibitor of metalloproteinase 3 (Timp3) antibody
  • tissue inhibitor of metalloproteinase-3 (TIMP-3) antibody
  • HSMRK222 antibody
  • IMP-3 antibody
  • K222 antibody
  • K222TA2 antibody
  • SFD antibody
  • Timp-3 antibody
  • timp3 antibody
  • timp3-A antibody

Protein level used designations for TIMP3

metalloproteinase inhibitor 3 , TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor metalloproteinase-3 , TIMP metallopeptidase inhibitor 3 , Metalloproteinase inhibitor 3 , MIG-5 protein , TIMP-3 , protein MIG-5 , tissue inhibitor of metalloproteinases 3 , tissue inhibitor of metalloproteinase-3 , tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor of metalloproteinase 3 , 21 kDa protein of extracellular matrix , tissue inhibitor of metalloproteinases-3

GENE ID SPECIES
6034728 Culex quinquefasciatus
481289 Canis lupus familiaris
100135460 Papio anubis
100196821 Salmo salar
7078 Homo sapiens
100008690 Oryctolagus cuniculus
25358 Rattus norvegicus
282094 Bos taurus
100033947 Equus caballus
396483 Gallus gallus
373596 Xenopus laevis
574381 Macaca mulatta
100217407 Ovis aries
21859 Mus musculus
396775 Sus scrofa
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