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Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). Additionally we are shipping TRAF7 Antibodies (26) and many more products for this protein.
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TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB (show NFKB1 Proteins) transcription factor.
These results suggest a new mechanism by which MyoD1 (show MYOD1 Proteins) function is coupled to NF-kappaB (show NFKB1 Proteins) activity through Traf7, regulating the balance between cell cycle progression and differentiation during myogenesis.
TRAF7 negatively regulates c-Myb (show MYB Proteins) activity by sequestering c-Myb (show MYB Proteins) to the cytosol via sumoylation.
TRAF7 is a direct target of miR (show MLXIP Proteins)-126 in human umbilical cord vascular endothelial cells.
Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 (show TP53 Proteins) in breast cancer.
The findings of this study suggested an essential contribution of combined KLF4 (show KLF4 Proteins) K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 (show NF2 Proteins) meningiomas.
Nearly one-fourth of all meningiomas have mutations in TRAF7.
an important role for TRAF7 in the activation of JNK (show MAPK8 Proteins) following TNFalpha (show TNF Proteins) stimulation and involvement of this protein in regulating the turnover of c-FLIP (show CFLAR Proteins)
this study identifies TRAF7 as a NEMO (show IKBKG Proteins)- and p65 (show GORASP1 Proteins)-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB (show NFKB1 Proteins) transcriptional activity.
TRAF7 potentiates MEKK3 (show MAP3K3 Proteins)-induced AP1 (show FOSB Proteins) and CHOP (show DDIT3 Proteins) activation and induces apoptosis
Tumor necrosis factor (TNF\; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs\; a coiled-coil (leucine zipper) motif\; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.
TNF receptor-associated factor 7
, ring finger and WD repeat domain 1
, E3 ubiquitin-protein ligase TRAF7
, e3 ubiquitin-protein ligase TRAF7-like
, RING finger and WD repeat-containing protein 1
, RING finger protein 119