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HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. Additionally we are shipping TNF Receptor-Associated Protein 1 Proteins (9) and many more products for this protein.
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Human Polyclonal TRAP1 Primary Antibody for ICC, IF - ABIN2482022
Felts, Owen, Nguyen, Trepel, Donner, Toft: The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. in The Journal of biological chemistry 2000
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Human Polyclonal TRAP1 Primary Antibody for ICC, IF - ABIN2482021
Costantino, Maddalena, Calise, Piscazzi, Tirino, Fersini, Ambrosi, Neri, Esposito, Landriscina: TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells. in Cancer letters 2009
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Human Polyclonal TRAP1 Primary Antibody for ICC, IF - ABIN2482025
Cechetto, Gupta: Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. in Experimental cell research 2000
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Dog (Canine) Monoclonal TRAP1 Primary Antibody for IF, WB - ABIN968825
Chen, Chen, Dai, Chen, Riley, Lee: A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. in Molecular and cellular biology 1996
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Human Polyclonal TRAP1 Primary Antibody for IHC, WB - ABIN2792093
Masuda, Shima, Aiuchi, Horie, Hori, Nakajo, Kajimoto, Shibayama-Imazu, Nakaya: Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. in The Journal of biological chemistry 2004
Human Polyclonal TRAP1 Primary Antibody for IHC (p), WB - ABIN658049
Leav, Plescia, Goel, Li, Jiang, Cohen, Languino, Altieri: Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. in The American journal of pathology 2009
TRAP1 is a downstream effector of BRAF (show BRAF Antibodies) cytoprotective pathway in mitochondria and TRAP1 targeting may represent a novel strategy to improve the activity of proapoptotic agents in BRAF (show BRAF Antibodies)-driven CRC (show CALR Antibodies) cells.
the association of rs2679860 polymorphisms of TGFBRAP1 (show TGFBRAP1 Antibodies) and DBP (show GC Antibodies) variation as well as plasma levels of TGF-beta1 (show TGFB1 Antibodies)
Our results indicate that GRP94 (show HSP90B1 Antibodies) and TRAP1 might contribute more to the carcinogenesis or biology of SCLC than HSP90alpha (show HSP90AA2 Antibodies) and HSP90beta (show HSP90AB1 Antibodies)
A previously unobserved coiled-coil dimer conformation may precede dimer closure. TRAP1 exists in an autoinhibited state with the ATP lid bound to the ATP-binding pocket. ATP displaces this and signals the cis (show CISH Antibodies)-bound ATP status to the next subunit.
results of the present study show that TRAP1 provides cardioprotection against myocardial I/R by ameliorating mitochondrial dysfunction
a correlation between TRAP1 and AKT expression is found in vivo in human colorectal tumours. These results provide new insights into TRAP1 role in the regulation of cell migration in cancer cells, tumour progression and metastatic mechanisms.
TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis in esophageal squamous cell cancer.
Our findings demonstrate that SDH inhibition by TRAP1 is oncogenic not only by inducing pseudohypoxia, but also by protecting tumor cells from oxidative stress
crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal beta-strand previously shown to cross between protomers in the closed state
Oxidative stress in ulcerative colitis could lead to the increase of cytoprotective protein TRAP1, which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.
Data show that the overexpression of heat shock protein 75 (Hsp75) decreased neural stem cells (NSCs) apoptosis and preserved mitochondrial membrane potential.
TRAP-1-/- mice are viable and show reduced incidence of age-associated pathologies. Loss of TRAP-1 upregulates oxidative phosphorylation and glycolysis transcriptomes.
overexpression of TRAP1 leads to mitochondrial aberrations, including an increase in basal ROS (show ROS1 Antibodies) levels and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma (show PPARG Antibodies) coactivator-1alpha mRNA levels
Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI (show DNASE1 Antibodies) by transcriptional interference.
TRAP1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis in immortalized mouse fibroblasts.
These data identify TRAP-1 as a novel mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate.
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
TNFR-associated protein 1
, heat shock protein 75 kDa, mitochondrial
, tumor necrosis factor type 1 receptor-associated protein
, HSP 75
, tumor necrosis factor type 1 receptor associated protein
, TGF beta receptor associated protein -1
, TGF-beta receptor-associated protein 1
, transforming growth factor-beta receptor-associated protein 1