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HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. Additionally we are shipping TNF Receptor-Associated Protein 1 Proteins (12) and TNF Receptor-Associated Protein 1 Kits (4) and many more products for this protein.
Showing 10 out of 174 products:
Human Polyclonal TRAP1 Primary Antibody for ICC, IF - ABIN2482022
Felts, Owen, Nguyen, Trepel, Donner, Toft: The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. in The Journal of biological chemistry 2000
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Human Polyclonal TRAP1 Primary Antibody for ICC, IF - ABIN2482021
Costantino, Maddalena, Calise, Piscazzi, Tirino, Fersini, Ambrosi, Neri, Esposito, Landriscina: TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells. in Cancer letters 2009
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Human Monoclonal TRAP1 Primary Antibody for ICC, IF - ABIN863110
Cechetto, Gupta: Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. in Experimental cell research 2000
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Dog (Canine) Monoclonal TRAP1 Primary Antibody for IF, WB - ABIN968825
Chen, Chen, Dai, Chen, Riley, Lee: A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. in Molecular and cellular biology 1996
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Human Monoclonal TRAP1 Primary Antibody for ICC, IF - ABIN152714
Hamacher-Brady, Choe, Krijnse-Locker, Brady: Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase. in Cell death and differentiation 2014
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Human Polyclonal TRAP1 Primary Antibody for IHC (p), WB - ABIN658049
Leav, Plescia, Goel, Li, Jiang, Cohen, Languino, Altieri: Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. in The American journal of pathology 2009
Dog (Canine) Polyclonal TRAP1 Primary Antibody for IHC, WB - ABIN2792093
Masuda, Shima, Aiuchi, Horie, Hori, Nakajo, Kajimoto, Shibayama-Imazu, Nakaya: Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. in The Journal of biological chemistry 2004
TRAP1 is often deleted in high-grade serous ovarian cancer patients.
TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.
overexpression of TRAP1 might contribute to tumor cell local invasion of colorectal cancer
Increased TRAP1 expression was significantly associated with EOC stages.
Overexpression of TRAP1 in breast cancer cells causes mitochondrial fusion, triggers mitochondria to form tubular networks, and suppresses cell migration and invasion in vitro and in vivo. These data link TRAP1-regulated mitochondrial dynamics and function with tumorigenesis in breast cancer.
TRAP1 is highly expressed in kidney cancer and correlates with patients prognosis
TRAP1 is a downstream effector of BRAF (show BRAF Antibodies) cytoprotective pathway in mitochondria and TRAP1 targeting may represent a novel strategy to improve the activity of proapoptotic agents in BRAF (show BRAF Antibodies)-driven CRC (show CALR Antibodies) cells.
the association of rs2679860 polymorphisms of TGFBRAP1 (show TGFBRAP1 Antibodies) and DBP (show GC Antibodies) variation as well as plasma levels of TGF-beta1 (show TGFB1 Antibodies)
Our results indicate that GRP94 (show HSP90B1 Antibodies) and TRAP1 might contribute more to the carcinogenesis or biology of SCLC than HSP90alpha (show HSP90AA2 Antibodies) and HSP90beta (show HSP90AB1 Antibodies)
A previously unobserved coiled-coil dimer conformation may precede dimer closure. TRAP1 exists in an autoinhibited state with the ATP lid bound to the ATP-binding pocket. ATP displaces this and signals the cis (show CISH Antibodies)-bound ATP status to the next subunit.
Data show that the overexpression of heat shock protein 75 (Hsp75) decreased neural stem cells (NSCs) apoptosis and preserved mitochondrial membrane potential.
TRAP-1-/- mice are viable and show reduced incidence of age-associated pathologies. Loss of TRAP-1 upregulates oxidative phosphorylation and glycolysis transcriptomes.
overexpression of TRAP1 leads to mitochondrial aberrations, including an increase in basal ROS (show ROS1 Antibodies) levels and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma (show PPARG Antibodies) coactivator-1alpha mRNA levels
Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI (show DNASE1 Antibodies) by transcriptional interference.
TRAP1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis in immortalized mouse fibroblasts.
These data identify TRAP-1 as a novel mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate.
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
TNFR-associated protein 1
, heat shock protein 75 kDa, mitochondrial
, tumor necrosis factor type 1 receptor-associated protein
, HSP 75
, tumor necrosis factor type 1 receptor associated protein
, TGF beta receptor associated protein -1
, TGF-beta receptor-associated protein 1
, transforming growth factor-beta receptor-associated protein 1