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Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Additionally we are shipping TNIP3 Proteins (2) and and many more products for this protein.
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Human Polyclonal TNIP3 Primary Antibody for EIA, IHC (p) - ABIN499187
Verstrepen, Carpentier, Verhelst, Beyaert: ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling. in Biochemical pharmacology 2009
Show all 4 references for ABIN499187
ABIN-3 is a novel negative feedback regulator of LPS (show IRF6 Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation
ABIN-3 is, thus, an IL-10 (show IL10 Antibodies)-induced gene product capable of attenuating NF-kappaB (show NFKB1 Antibodies) in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 (show IL10 Antibodies) actions.
Enhanced expression of ABIN-3 in monocytes is associated with sepsis
This review defines ABIN-3 based on three different parameters: ability to bind A20 (show TNFAIP3 Antibodies); ability to inhibit NF-kappaB (show NFKB1 Antibodies) activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains.
adiponectin (show ADIPOQ Antibodies) augmented the expression of A20 (show TNFAIP3 Antibodies), suppressor of cytokine signaling (SOCS (show CISH Antibodies)) 3 (show SOCS3 Antibodies), B-cell CLL/lymphoma (BCL) 3 (show BCL3 Antibodies), TNF (show TNF Antibodies) receptor-associated factor (TRAF) 1 (show TRAF1 Antibodies), and TNFAIP3 (show TNFAIP3 Antibodies)-interacting protein (TNIP) 3.
Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
TNFAIP3 interacting protein 3
, A20-binding inhibitor of NF-kappa-B activation 3
, ABIN-3 beta
, Listeria induced
, TNFAIP3-interacting protein 3
, TNFAIP3-interacting protein 3 beta
, TNIP3 beta
, listeria-induced gene protein
, RIKEN cDNA 9030611K07