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Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Additionally we are shipping TNIP3 Antibodies (45) and and many more products for this protein.
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ABIN-3 is a novel negative feedback regulator of LPS (show IRF6 Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation
ABIN-3 is, thus, an IL-10 (show IL10 Proteins)-induced gene product capable of attenuating NF-kappaB (show NFKB1 Proteins) in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 (show IL10 Proteins) actions.
Enhanced expression of ABIN-3 in monocytes is associated with sepsis
This review defines ABIN-3 based on three different parameters: ability to bind A20 (show TNFAIP3 Proteins); ability to inhibit NF-kappaB (show NFKB1 Proteins) activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains.
adiponectin (show ADIPOQ Proteins) augmented the expression of A20 (show TNFAIP3 Proteins), suppressor of cytokine signaling (SOCS (show CISH Proteins)) 3 (show SOCS3 Proteins), B-cell CLL/lymphoma (BCL) 3 (show BCL3 Proteins), TNF (show TNF Proteins) receptor-associated factor (TRAF) 1 (show TRAF1 Proteins), and TNFAIP3 (show TNFAIP3 Proteins)-interacting protein (TNIP) 3.
Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
TNFAIP3 interacting protein 3
, A20-binding inhibitor of NF-kappa-B activation 3
, ABIN-3 beta
, Listeria induced
, TNFAIP3-interacting protein 3
, TNFAIP3-interacting protein 3 beta
, TNIP3 beta
, listeria-induced gene protein
, RIKEN cDNA 9030611K07