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The protein encoded by TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. Additionally we are shipping TOX3 Proteins (4) and many more products for this protein.
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Human Polyclonal TOX3 Primary Antibody for ELISA, WB - ABIN334513
Easton, Pooley, Dunning, Pharoah, Thompson, Ballinger, Struewing, Morrison, Field, Luben, Wareham, Ahmed, Healey, Bowman, Meyer, Haiman, Kolonel, Henderson, Le Marchand, Brennan, Sangrajrang et al.: Genome-wide association study identifies novel breast cancer susceptibility loci. ... in Nature 2007
TNRC9 GG genotype of rs3803662 is associated with increased breast cancer risk.
The TOX3 SNPs rs3803662 C > T, rs12443621 A > G and rs8051542 C > T were all correlated with increased risk of breast cancer in the European and Asian populations, but not in the African one.
TOX3 and FGFR2 are breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population.
TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer
Single nucleotide polymorphism in TOX3 gene is associated with breast cancer risk.
data suggest that central inhibition of IL-1alpha or Tox3 overexpression during the acute phase of a CNS insult may be an effective means for preventing the loss of neurological function
Mutations in TOX3 are not common in Chinese Han women with polycystic ovary syndrome.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (show BTBD9 Antibodies), TOX3/BC034767, MEIS1 (show MEIS1 Antibodies), MAP2K5 (show MAP2K5 Antibodies)/SKOR1 (show SKOR1 Antibodies), and PTPRD (show PTPRD Antibodies)
These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042 alleles for breast cancer risk.
The T-rs8051542 allele was significantly associated with ER-positive and HER2 (show ERBB2 Antibodies)-negative carriers. No significant association existed between rs12443621, rs3803662, and rs3112612 polymorphisms and risk of breast cancer.
A role of Tox3 in the development of the nervous system.
TNRC9 gene is amplified and associated with poor prognosis in advanced breast cancer. TNRC9 promotes cancer cell proliferation, migration, and survival both in vitro and in vivo. TNRC9 and BRCA1 expression are inversely correlated.
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.
TOX high mobility group box family member 3
, trinucleotide repeat containing 9
, TOX high mobility group box family member 3-like
, CAG trinucleotide repeat-containing gene F9 protein
, trinucleotide repeat-containing gene 9 protein