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TP53 Apoptosis Effector Proteins (PERP)

Component of intercellular desmosome junctions. Additionally we are shipping PERP Antibodies (63) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PERP 64058 Q9JK95
PERP 64065 Q96FX8
Rat PERP PERP 292949  
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Top PERP Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PERP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for TP53 Apoptosis Effector (PERP) Interaction Partners

Zebrafish TP53 Apoptosis Effector (PERP) interaction partners

  1. In contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival.

Mouse (Murine) TP53 Apoptosis Effector (PERP) interaction partners

  1. Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation

  2. an important role for Perp in normal mammary tissue function and in mammary cancer suppression

  3. Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation.

  4. Studies suggest that Perp-deficiency promotes cancer by enhancing cell surv (show CDH1 Proteins)ival, desmosome loss, and inflammatio (show CYP11A1 Proteins)n, and they highlight a fundamental role for Perp and desmosomes in tumor suppression.

  5. In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation

  6. Perp is a key effector in the p63 (show CKAP4 Proteins) developmental program.

  7. Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings.

  8. Perp is requered throughout adult life for proper epithelial homeostasis and function.

  9. PERP, a p53 (show TP53 Proteins) proapoptotic target, mediates apoptotic cell death in renal ischemia.

  10. pemphigus vulgaris (show DSG3 Proteins) autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 (show DSG3 Proteins) into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation

Human TP53 Apoptosis Effector (PERP) interaction partners

  1. The authors identified the tetraspanning membrane protein, p53 (show TP53 Proteins) effector related to PMP-22 (show PMP22 Proteins) (PERP), as a Salmonella typhimurium SipA binding partner.

  2. Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.

  3. Perp expression is reduced in human breast cancer cell lines

  4. PERP expression stabilizes active p53 (show TP53 Proteins) via modulation of p53 (show TP53 Proteins)-MDM2 (show MDM2 Proteins) interaction in uveal melanoma cells.

  5. Data suggest a temporal sequence whereby PERP loss occurs before E-cadherin (show CDH1 Proteins) loss in the progression of human SCC (show CYP11A1 Proteins).

  6. findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by uveal melanoma tumours to modulate susceptibility to apoptosis

  7. pemphigus vulgaris (show DSG3 Proteins) autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 (show DSG3 Proteins) into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation

  8. We demonstrate here that PERP induction is in fact compromised with some, but not all, Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate, AEC-patient derived TP63 (show TP63 Proteins) mutants.

  9. A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor (show TP53 Proteins), which is selectively induced during apoptosis compared to cell cycle arrest.

PERP Protein Profile

Protein Summary

Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).

Gene names and symbols associated with TP53 Apoptosis Effector Proteins (PERP)

  • TP53 apoptosis effector (LOC421682)
  • PERP, TP53 apoptosis effector (PERP)
  • PERP, TP53 apoptosis effector (perp)
  • PERP, TP53 apoptosis effector (LOC100221212)
  • PERP, TP53 apoptosis effector (Perp)
  • 1110017A08Rik protein
  • dJ496H19.1 protein
  • fk24g11 protein
  • KCP1 protein
  • KRTCAP1 protein
  • LOC100221212 protein
  • PERP protein
  • PERPL protein
  • PIGPC1 protein
  • RP3-496H19.1 protein
  • THW protein
  • wu:fk24g11 protein

Protein level used designations for TP53 Apoptosis Effector Proteins (PERP)

PERP, TP53 apoptosis effector , TP53 apoptosis effector , p53 apoptosis effector related to PMP-22 , rp3-496h19.1 , p53 apoptosis effector related to pmp-22 , KCP-1 , keratinocyte-associated protein 1 , p53 apoptosis effector related to Pmp22 , p53 apoptosis-associated target , 1110017A08Rik , keratinocytes associated protein 1 , p53 apoptosis effector related to PMP22 , p53-induced protein PIGPC1 , transmembrane protein THW

GENE ID SPECIES
421682 Gallus gallus
421683 Gallus gallus
444660 Xenopus laevis
494479 Danio rerio
548916 Xenopus (Silurana) tropicalis
703890 Macaca mulatta
100025866 Monodelphis domestica
100067837 Equus caballus
100221212 Taeniopygia guttata
100528358 Ictalurus punctatus
64058 Mus musculus
64065 Homo sapiens
476218 Canis lupus familiaris
292949 Rattus norvegicus
509485 Bos taurus
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